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Manti S, Romano C, Chirico V, et al. Nonalcoholic Fatty liver disease/non-alcoholic steatohepatitis in childhood: endocrine-metabolic "mal-programming". Hepat Mon. 2014;14(5):e17641doi: 10.5812/hepatmon.17641.
Manti, S., Romano, C., Chirico, V., Filippelli, M., Cuppari, C., Loddo, I., Salpietro, C., & Arrigo, T. (2014). Nonalcoholic Fatty liver disease/non-alcoholic steatohepatitis in childhood: endocrine-metabolic "mal-programming". Hepatitis monthly, 14(5), e17641. https://doi.org/10.5812/hepatmon.17641
Manti, Sara, et al. "Nonalcoholic Fatty liver disease/non-alcoholic steatohepatitis in childhood: endocrine-metabolic "mal-programming"." Hepatitis monthly vol. 14,5 (2014): e17641. doi: https://doi.org/10.5812/hepatmon.17641
Manti S, Romano C, Chirico V, Filippelli M, Cuppari C, Loddo I, Salpietro C, Arrigo T. Nonalcoholic Fatty liver disease/non-alcoholic steatohepatitis in childhood: endocrine-metabolic "mal-programming". Hepat Mon. 2014 May 01;14(5):e17641. doi: 10.5812/hepatmon.17641. eCollection 2014 May. PMID: 24829591; PMCID: PMC4013495.
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Hepat Mon. 2014 May 01;14(5):e17641. doi: 10.5812/hepatmon.17641. eCollection 2014 May.

Nonalcoholic Fatty liver disease/non-alcoholic steatohepatitis in childhood: endocrine-metabolic "mal-programming".

Hepatitis monthly

Sara Manti, Claudio Romano, Valeria Chirico, Martina Filippelli, Caterina Cuppari, Italia Loddo, Carmelo Salpietro, Teresa Arrigo

Affiliations

  1. Department of Pediatric Sciences, Genetics and Pediatric Immunology Unit, University of Messina, Messina, Italy.

PMID: 24829591 PMCID: PMC4013495 DOI: 10.5812/hepatmon.17641

Abstract

CONTEXT: Nonalcoholic Fatty Liver Disease (NAFLD) is the major chronic liver disease in the pediatric population. NAFLD includes a broad spectrum of abnormalities (inflammation, fibrosis and cirrhosis), ranging from accumulation of fat (also known as steatosis) towards non-alcoholic steatohepatitis (NASH). The development of NAFLD in children is significantly increased.

EVIDENCE ACQUISITION: A literature search of electronic databases was undertaken for the major studies published from 1998 to today. The databases searched were: PubMed, EMBASE, Orphanet, Midline and Cochrane Library. We used the key words: "non-alcoholic fatty liver disease, children, non-alcoholic steatohepatitis and fatty liver".

RESULTS: NAFLD/NASH is probably promoted by "multiple parallel hits": environmental and genetic factors, systemic immunological disorders (oxidative stress, persistent-low grade of inflammation) as well as obesity and metabolic alterations (insulin resistance and metabolic syndrome). However its exact cause still underdiagnosed and unknown.

CONCLUSIONS: Pediatric NAFLD/NASH is emerging problem. Longitudinal follow-up studies, unfortunately still insufficient, are needed to better understand the natural history and outcome of NAFLD in children. This review focuses on the current knowledge regarding the epidemiology, pathogenesis, environmental, genetic and metabolic factors of disease. The review also highlights the importance of studying the underlying mechanisms of pediatric NAFLD and the need for complete and personalized approach in the management of NAFLD/NASH.

Keywords: Mallory Bodies; Non-Alcoholic Fatty Liver Disease; Oxidative Stress

References

  1. BMC Pediatr. 2013 Mar 25;13:40 - PubMed
  2. PLoS One. 2011;6(12):e28502 - PubMed
  3. Gastroenterology. 1998 Apr;114(4):842-5 - PubMed
  4. PLoS One. 2012;7(8):e42259 - PubMed
  5. J Pediatr. 2003 Oct;143(4):500-5 - PubMed
  6. Gene. 2013 Oct 25;529(2):326-31 - PubMed
  7. J Hepatol. 2007 May;46(5):915-20 - PubMed
  8. Nat Med. 2005 Feb;11(2):183-90 - PubMed
  9. J Hepatol. 2012 Dec;57(6):1312-8 - PubMed
  10. Nature. 2006 Dec 21;444(7122):1027-31 - PubMed
  11. Int J Obes Relat Metab Disord. 2004 Oct;28(10):1257-63 - PubMed
  12. Toxicol Appl Pharmacol. 2014 Jan 1;274(1):42-54 - PubMed
  13. J Clin Endocrinol Metab. 2008 Nov;93(11):4479-85 - PubMed
  14. Gastroenterology. 2001 Apr;120(5):1183-92 - PubMed
  15. Obes Surg. 2007 Nov;17(11):1457-63 - PubMed
  16. Hepatology. 2005 Sep;42(3):641-9 - PubMed
  17. Subcell Biochem. 2013;67:165-75 - PubMed
  18. J Pediatr. 2000 Jun;136(6):727-33 - PubMed
  19. Diabetes Metab Res Rev. 2002 Mar-Apr;18 Suppl 2:S5-9 - PubMed
  20. Acta Biomed. 2009 Apr;80(1):21-8 - PubMed
  21. J Clin Gastroenterol. 2006 Mar;40 Suppl 1:S30-3 - PubMed
  22. J Hepatol. 2011 Dec;55(6):1409-14 - PubMed
  23. Int J Mol Sci. 2013 Oct 15;14(10):20704-28 - PubMed
  24. J Hepatol. 2006 Jun;44(6):1196-207 - PubMed
  25. Metabolism. 2005 Sep;54(9):1155-61 - PubMed
  26. Hypertens Res. 2010 Jun;33(6):546-7 - PubMed
  27. Eur J Endocrinol. 2013 Mar 15;168(4):631-8 - PubMed
  28. J Clin Endocrinol Metab. 2006 Nov;91(11):4287-94 - PubMed
  29. Eur J Endocrinol. 2006 May;154(5):691-7 - PubMed
  30. Saudi J Gastroenterol. 2011 Jul-Aug;17(4):265-70 - PubMed
  31. J Pediatr. 2009 Oct;155(4):469-74 - PubMed
  32. J Pediatr. 2014 Apr;164(4):707-713.e3 - PubMed
  33. N Engl J Med. 2004 Jun 3;350(23):2362-74 - PubMed
  34. J Gastroenterol Hepatol. 2013 Aug;28 Suppl 1:38-42 - PubMed
  35. J Pediatr Gastroenterol Nutr. 2014 May;58(5):632-6 - PubMed
  36. Nutrients. 2013 Oct 11;5(10):4093-114 - PubMed
  37. Hepat Mon. 2014 Jan 03;14(1):e15167 - PubMed
  38. J Biol Chem. 2004 May 7;279(19):20314-26 - PubMed
  39. Am J Clin Nutr. 2009 Mar;89(3):980S-984S - PubMed
  40. Gastroenterology. 1999 Jun;116(6):1413-9 - PubMed
  41. Gastroenterology. 2008 Jul;135(1):282-291.e1 - PubMed
  42. Science. 1993 Jan 1;259(5091):87-91 - PubMed
  43. Diabetes Care. 2011 May;34 Suppl 2:S171-6 - PubMed
  44. Hepatology. 2012 Mar;55(3):781-9 - PubMed
  45. J Clin Invest. 2002 May;109(9):1125-31 - PubMed
  46. Am J Gastroenterol. 1999 Sep;94(9):2467-74 - PubMed
  47. Gene. 2013 Oct 25;529(2):340-4 - PubMed
  48. Dig Dis Sci. 2009 Oct;54(10):2225-30 - PubMed
  49. Am J Gastroenterol. 2010 Sep;105(9):2093-102 - PubMed
  50. Proc Nutr Soc. 2010 May;69(2):211-20 - PubMed
  51. Science. 2011 Jun 24;332(6037):1519-23 - PubMed
  52. Curr Opin Pediatr. 2009 Aug;21(4):529-35 - PubMed
  53. Am J Gastroenterol. 2006 Oct;101(10):2247-53 - PubMed
  54. J Clin Endocrinol Metab. 2008 Aug;93(8):3051-7 - PubMed
  55. J Clin Invest. 1999 Jan;103(2):253-9 - PubMed
  56. Hepatology. 2012 May;55(5):1389-97 - PubMed
  57. Diabetologia. 2005 Apr;48(4):634-42 - PubMed
  58. Mitochondrion. 2006 Feb;6(1):1-28 - PubMed
  59. J Anim Sci. 2008 Apr;86(14 Suppl):E94-104 - PubMed
  60. Gut. 2012 Jul;61(7):1058-67 - PubMed
  61. Diabet Med. 1998 Jul;15(7):539-53 - PubMed
  62. Free Radic Biol Med. 2012 Nov 15;53(10):1829-37 - PubMed
  63. Hepatology. 2007 May;45(5):1097-107 - PubMed
  64. J Biol Chem. 2009 Mar 6;284(10):6116-25 - PubMed
  65. Int J Immunopathol Pharmacol. 2011 Oct;24(4 Suppl):33-40 - PubMed
  66. Clin Endocrinol (Oxf). 2013 Oct;79(4):537-44 - PubMed
  67. Mol Metab. 2013 Aug 03;2(4):435-46 - PubMed
  68. Int Arch Allergy Immunol. 2013;161(2):116-21 - PubMed
  69. Dig Liver Dis. 2009 Nov;41(11):823-8 - PubMed
  70. Saudi J Gastroenterol. 2012 Jan-Feb;18(1):44-9 - PubMed
  71. Pediatrics. 2009 Dec;124(6):e1221-7 - PubMed
  72. PLoS One. 2012;7(5):e37827 - PubMed
  73. Gastroenterology. 2008 May;134(5):1369-75 - PubMed
  74. Nature. 2001 Jan 18;409(6818):307-12 - PubMed

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