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Schnell E, Long TH, Bensen AL, et al. Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons. Front Neurosci. 2014;8:71doi: 10.3389/fnins.2014.00071.
Schnell, E., Long, T. H., Bensen, A. L., Washburn, E. K., & Westbrook, G. L. (2014). Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons. Frontiers in neuroscience, 871. https://doi.org/10.3389/fnins.2014.00071
Schnell, Eric, et al. "Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons." Frontiers in neuroscience vol. 8 (2014): 71. doi: https://doi.org/10.3389/fnins.2014.00071
Schnell E, Long TH, Bensen AL, Washburn EK, Westbrook GL. Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons. Front Neurosci. 2014 Apr 10;8:71. doi: 10.3389/fnins.2014.00071. eCollection 2014. PMID: 24782702; PMCID: PMC3989658.
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Front Neurosci. 2014 Apr 10;8:71. doi: 10.3389/fnins.2014.00071. eCollection 2014.

Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons.

Frontiers in neuroscience

Eric Schnell, Thomas H Long, Aesoon L Bensen, Eric K Washburn, Gary L Westbrook

Affiliations

  1. Portland VA Medical Center Portland, OR, USA ; Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University Portland, OR, USA.
  2. School of Medicine, Oregon Health and Science University Portland, OR, USA.
  3. The Vollum Institute, Oregon Health and Science University Portland, OR, USA.

PMID: 24782702 PMCID: PMC3989658 DOI: 10.3389/fnins.2014.00071

Abstract

Survival of adult-born hippocampal granule cells is modulated by neural activity, and thought to be enhanced by excitatory synaptic signaling. Here, we report that a reduction in the synaptogenic protein neuroligin-1 in adult-born neurons in vivo decreased their survival, but surprisingly, this effect was independent of changes in excitatory synaptic function. Instead, the decreased survival was associated with unexpected changes in dendrite and spine morphology during granule cell maturation, suggesting a link between cell growth and survival.

Keywords: adult neurogenesis; cell survival; dendritic growth; dendritic spine; neuroligin-1; synaptogenesis

References

  1. PLoS One. 2011 Mar 07;6(3):e16998 - PubMed
  2. Nat Neurosci. 2012 Dec;15(12):1667-74 - PubMed
  3. Front Synaptic Neurosci. 2013 Aug 20;5:4 - PubMed
  4. J Neurosci. 2005 Nov 2;25(44):10074-86 - PubMed
  5. Eur J Neurosci. 2007 Oct;26(7):1738-48 - PubMed
  6. Nature. 2006 Aug 24;442(7105):929-33 - PubMed
  7. Nat Neurosci. 2011 Jun;14(6):718-26 - PubMed
  8. Neuron. 2012 Oct 18;76(2):309-16 - PubMed
  9. Nat Neurosci. 1999 Mar;2(3):260-5 - PubMed
  10. Neuron. 2006 Sep 21;51(6):741-54 - PubMed
  11. Neuron. 2010 Sep 23;67(6):967-83 - PubMed
  12. Nature. 1997 Apr 3;386(6624):493-5 - PubMed
  13. J Neurosci. 2005 Jan 26;25(4):869-79 - PubMed
  14. Cell Stem Cell. 2010 Oct 8;7(4):483-95 - PubMed
  15. PLoS One. 2012;7(10):e48045 - PubMed
  16. J Neurosci. 2006 Jan 4;26(1):3-11 - PubMed
  17. Hippocampus. 2010 Jul;20(7):799-810 - PubMed
  18. Neuron. 1996 Jul;17(1):91-102 - PubMed
  19. J Neurosci. 2005 Feb 2;25(5):1089-94 - PubMed
  20. Nature. 1999 May 6;399(6731):66-70 - PubMed
  21. PLoS One. 2011;6(5):e19077 - PubMed
  22. Science. 1997 Sep 5;277(5331):1511-5 - PubMed
  23. J Neurosci. 2013 Jul 24;33(30):12229-41 - PubMed
  24. Epilepsia. 2008 Jun;49 Suppl 5:3-12 - PubMed
  25. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7963-8 - PubMed
  26. Curr Opin Neurobiol. 2007 Feb;17(1):43-52 - PubMed
  27. Nat Rev Neurosci. 2000 Dec;1(3):191-8 - PubMed
  28. Development. 2003 Jan;130(2):391-9 - PubMed
  29. Nat Neurosci. 2007 Jun;10(6):727-34 - PubMed
  30. Neuron. 2011 May 26;70(4):687-702 - PubMed
  31. Annu Rev Physiol. 2002;64:355-405 - PubMed
  32. J Neurosci Res. 2002 Sep 15;69(6):745-9 - PubMed
  33. Nature. 2008 Oct 16;455(7215):903-11 - PubMed
  34. Nature. 2002 Feb 28;415(6875):1030-4 - PubMed
  35. J Neurosci. 1996 May 1;16(9):2983-94 - PubMed
  36. Science. 2005 Feb 25;307(5713):1324-8 - PubMed

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