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Schaller T, Bauby H, Hué S, et al. New insights into an X-traordinary viral protein. Front Microbiol. 2014;5:126doi: 10.3389/fmicb.2014.00126.
Schaller, T., Bauby, H., Hué, S., Malim, M. H., & Goujon, C. (2014). New insights into an X-traordinary viral protein. Frontiers in microbiology, 5126. https://doi.org/10.3389/fmicb.2014.00126
Schaller, Torsten, et al. "New insights into an X-traordinary viral protein." Frontiers in microbiology vol. 5 (2014): 126. doi: https://doi.org/10.3389/fmicb.2014.00126
Schaller T, Bauby H, Hué S, Malim MH, Goujon C. New insights into an X-traordinary viral protein. Front Microbiol. 2014 Apr 08;5:126. doi: 10.3389/fmicb.2014.00126. eCollection 2014. PMID: 24782834; PMCID: PMC3986551.
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Front Microbiol. 2014 Apr 08;5:126. doi: 10.3389/fmicb.2014.00126. eCollection 2014.

New insights into an X-traordinary viral protein.

Frontiers in microbiology

Torsten Schaller, Hélène Bauby, Stéphane Hué, Michael H Malim, Caroline Goujon

Affiliations

  1. Department of Infectious Diseases, King's College London London, UK.
  2. Department of Infection, Division of Infection and Immunity, Centre for Medical Molecular Virology, University College London London, UK.

PMID: 24782834 PMCID: PMC3986551 DOI: 10.3389/fmicb.2014.00126

Abstract

Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. Vpx plays a critical role during the early steps of the viral life cycle and has been shown to counteract SAMHD1, a restriction factor in myeloid and resting T cells. However, it is becoming evident that Vpx is a multifunctional protein in that SAMHD1 antagonism is likely not its sole role. This review summarizes the current knowledge on this X-traordinary protein.

Keywords: HIV-1; HIV-2; SAMHD1; SIVsmm; interferon type I; myeloid cells; restriction factor; vpx

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