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Fooksman DR. Organizing MHC Class II Presentation. Front Immunol. 2014;5:158doi: 10.3389/fimmu.2014.00158.
Fooksman, D. R. (2014). Organizing MHC Class II Presentation. Frontiers in immunology, 5158. https://doi.org/10.3389/fimmu.2014.00158
Fooksman, David R. "Organizing MHC Class II Presentation." Frontiers in immunology vol. 5 (2014): 158. doi: https://doi.org/10.3389/fimmu.2014.00158
Fooksman DR. Organizing MHC Class II Presentation. Front Immunol. 2014 Apr 10;5:158. doi: 10.3389/fimmu.2014.00158. eCollection 2014. PMID: 24782863; PMCID: PMC3989578.
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Front Immunol. 2014 Apr 10;5:158. doi: 10.3389/fimmu.2014.00158. eCollection 2014.

Organizing MHC Class II Presentation.

Frontiers in immunology

David R Fooksman

Affiliations

  1. Department of Pathology, Albert Einstein College of Medicine , Bronx, NY , USA.

PMID: 24782863 PMCID: PMC3989578 DOI: 10.3389/fimmu.2014.00158

Abstract

Major histocompatibility complex (MHC) class II molecules are ligands for CD4(+) T cells and are critical for initiating the adaptive immune response. This review is focused on what is currently known about MHC class II organization at the plasma membrane of antigen presenting cells and how this affects antigen presentation to T cells. The organization and diffusion of class II molecules have been measured by a variety of biochemical and microscopic techniques. Membrane lipids and other proteins have been implicated in MHC class II organization and function. However, when compared with the organization of MHC class I or TCR complexes, much less is known about MHC class II. Since clustering of T cell receptors occurs during activation, the organization of MHC molecules prior to recognition and during synapse formation may be critical for antigen presentation.

Keywords: MHC class II; antigen presentation; clustering; diffusion; fluorescence; microscopy

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