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Kautbally S, Alexopoulou O, Daumerie C, et al. Greater Efficacy of Total Thyroidectomy versus Radioiodine Therapy on Hyperthyroidism and Thyroid-Stimulating Immunoglobulin Levels in Patients with Graves' Disease Previously Treated with Antithyroid Drugs. Eur Thyroid J. 2012;1(2):122-8doi: 10.1159/000339473.
Kautbally, S., Alexopoulou, O., Daumerie, C., Jamar, F., Mourad, M., & Maiter, D. (2012). Greater Efficacy of Total Thyroidectomy versus Radioiodine Therapy on Hyperthyroidism and Thyroid-Stimulating Immunoglobulin Levels in Patients with Graves' Disease Previously Treated with Antithyroid Drugs. European thyroid journal, 1(2), 122-8. https://doi.org/10.1159/000339473
Kautbally, Shakeel, et al. "Greater Efficacy of Total Thyroidectomy versus Radioiodine Therapy on Hyperthyroidism and Thyroid-Stimulating Immunoglobulin Levels in Patients with Graves' Disease Previously Treated with Antithyroid Drugs." European thyroid journal vol. 1,2 (2012): 122-8. doi: https://doi.org/10.1159/000339473
Kautbally S, Alexopoulou O, Daumerie C, Jamar F, Mourad M, Maiter D. Greater Efficacy of Total Thyroidectomy versus Radioiodine Therapy on Hyperthyroidism and Thyroid-Stimulating Immunoglobulin Levels in Patients with Graves' Disease Previously Treated with Antithyroid Drugs. Eur Thyroid J. 2012 Jul;1(2):122-8. doi: 10.1159/000339473. Epub 2012 Jun 20. PMID: 24783007; PMCID: PMC3821471.
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Eur Thyroid J. 2012 Jul;1(2):122-8. doi: 10.1159/000339473. Epub 2012 Jun 20.

Greater Efficacy of Total Thyroidectomy versus Radioiodine Therapy on Hyperthyroidism and Thyroid-Stimulating Immunoglobulin Levels in Patients with Graves' Disease Previously Treated with Antithyroid Drugs.

European thyroid journal

Shakeel Kautbally, Orsalia Alexopoulou, Chantal Daumerie, François Jamar, Michel Mourad, Dominique Maiter

Affiliations

  1. Division of Endocrinology and Nutrition, St. Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium.
  2. Division of Nuclear Medicine, St. Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium.
  3. Division of Endocrine Surgery, St. Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium.

PMID: 24783007 PMCID: PMC3821471 DOI: 10.1159/000339473

Abstract

AIMS: We compared the effects of total thyroidectomy (TTx) and radioiodine (RAI) administration on the course of thyroid hormones and thyroid-stimulating immunoglobulins (TSI) in patients with Graves' disease.

METHODS: We retrospectively studied 80 patients initially treated with antithyroid drugs and requiring either RAI (8.3 ± 1.7 mCi of (131)I; n = 40) or TTx (n = 40) as second-line therapy.

RESULTS: The TTx and RAI groups were not different, except for larger goiter, higher FT3 and more frequent Graves' orbitopathy at diagnosis in the surgery group (p < 0.05). A persistent remission of hyperthyroidism was observed in 97% of operated patients versus 73% of the RAI patients at 3 years (p < 0.01). TTx was followed by a rapid and steady decrease in TSI during the first 9 months, while a surge of antibodies was observed during the first 6 months after RAI, followed by a slow decrease over the next 18 months. At the last visit, high TSI levels were still observed in 18 and 60% of patients in the surgery and RAI groups, respectively (p < 0.001).

CONCLUSIONS: TTx is more efficient than RAI to induce a rapid and permanent correction of hyperthyroidism and TSI decrease in patients previously treated with antithyroid drugs.

Keywords: Graves' disease; Hyperthyroidism; Radioiodine therapy; Thyroid-stimulating immunoglobulin; Total thyroidectomy

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