Display options
Cite
Vergani L. Lipid lowering effects of iodothyronines: In vivo and in vitro studies on rat liver. World J Hepatol. 2014;6(4):169-77doi: 10.4254/wjh.v6.i4.169.
Vergani, L. (2014). Lipid lowering effects of iodothyronines: In vivo and in vitro studies on rat liver. World journal of hepatology, 6(4), 169-77. https://doi.org/10.4254/wjh.v6.i4.169
Vergani, Laura. "Lipid lowering effects of iodothyronines: In vivo and in vitro studies on rat liver." World journal of hepatology vol. 6,4 (2014): 169-77. doi: https://doi.org/10.4254/wjh.v6.i4.169
Vergani L. Lipid lowering effects of iodothyronines: In vivo and in vitro studies on rat liver. World J Hepatol. 2014 Apr 27;6(4):169-77. doi: 10.4254/wjh.v6.i4.169. PMID: 24799985; PMCID: PMC4009472.
Copy Download .nbib Format: NLM
Share it on

World J Hepatol. 2014 Apr 27;6(4):169-77. doi: 10.4254/wjh.v6.i4.169.

Lipid lowering effects of iodothyronines: In vivo and in vitro studies on rat liver.

World journal of hepatology

Laura Vergani

Affiliations

  1. Laura Vergani, Dipartimento di Scienze della Terra, dell'Ambiente e della Vita, Università degli Studi di Genova, 16132 Genova, Italy.

PMID: 24799985 PMCID: PMC4009472 DOI: 10.4254/wjh.v6.i4.169

Abstract

Non-alcoholic fatty liver disease (NAFLD) is emerging as one of the most common liver diseases, leading to the increasing interest for new therapeutic approaches for its treatment. NAFLD primarily depends on a hypercaloric and/or unbalanced diet leading to overweight and obesity. The liver, in fact, plays a central role in lipid metabolism by importing free fatty acids from the blood and synthesizing, storing, oxidizing and exporting lipids. Furthermore, the liver is the target for the thyroid hormones, thyroxine (T4) and 3,3',5-triiodo-L-thyronine (T3), that stimulate the basal metabolic rate and lead to body weight loss. In the last decade, other iodothyronines have been shown to possess biological relevance and play some thyromimetic activities; in particular, 3,5-diiodo-L-thyronine (T2) gained large interest. The global effect of iodothyronines on liver lipid metabolism results from the balance between direct and indirect actions on the hepatocyte, leading to stimulation of lipid synthesis, oxidation and autophagy. In this review, the results so far obtained on both in vivo and in vitro models of hepatosteatosis are summarized in order to obtain an updated picture of the lipid-lowering effects of iodothyronines on mammalian liver.

Keywords: Hepatocytes; Iodothyronines; Lipid metabolism; Liver steatosis; Non-alcoholic fatty liver disease

References

  1. ISRN Gastroenterol. 2011;2011:592404 - PubMed
  2. FASEB J. 2010 Jan;24(1):93-104 - PubMed
  3. J Endocrinol. 2011 Jul;210(1):59-69 - PubMed
  4. Trends Endocrinol Metab. 2005 Nov;16(9):429-35 - PubMed
  5. Biochem J. 1989 Mar 1;258(2):363-7 - PubMed
  6. Am J Physiol Gastrointest Liver Physiol. 2006 Feb;290(2):G194-8 - PubMed
  7. Eur J Biochem. 1998 Mar 1;252(2):325-30 - PubMed
  8. J Endocrinol. 2012 Feb;212(2):149-58 - PubMed
  9. Int J Mol Sci. 2013 Jun 05;14(6):11963-80 - PubMed
  10. J Biol Chem. 2000 Jul 21;275(29):21785-8 - PubMed
  11. Liver. 2000 Jun;20(3):191-9 - PubMed
  12. Biol Rev Camb Philos Soc. 2000 Nov;75(4):519-631 - PubMed
  13. Biochim Biophys Acta. 2009 Jun;1791(6):419-40 - PubMed
  14. J Biol Chem. 2009 Feb 27;284(9):5637-44 - PubMed
  15. Prog Lipid Res. 2009 Jan;48(1):1-26 - PubMed
  16. Biochem J. 1989 Aug 1;261(3):945-50 - PubMed
  17. Chem Biol Interact. 2007 Jan 30;165(2):106-16 - PubMed
  18. Endocrinology. 2004 Apr;145(4):1708-17 - PubMed
  19. Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G852-8 - PubMed
  20. Nature. 1986 Dec 18-31;324(6098):641-6 - PubMed
  21. Biochemistry (Mosc). 2005 Feb;70(2):164-72 - PubMed
  22. Thyroid. 1998 Sep;8(9):815-25 - PubMed
  23. J Physiol. 1996 Aug 1;494 ( Pt 3):831-7 - PubMed
  24. Nature. 1986 Dec 18-31;324(6098):635-40 - PubMed
  25. FASEB J. 2008 Aug;22(8):2981-9 - PubMed
  26. Thyroid. 2008 Feb;18(2):145-56 - PubMed
  27. Diabet Med. 2005 Sep;22(9):1129-33 - PubMed
  28. Hepatology. 2009 Apr;49(4):1176-84 - PubMed
  29. Biochim Biophys Acta. 2009 Jun;1791(6):448-58 - PubMed
  30. Hepatology. 2004 Jul;40(1):185-94 - PubMed
  31. J Clin Invest. 1991 Jan;87(1):125-32 - PubMed
  32. Biochem Biophys Res Commun. 2006 Feb 24;340(4):1111-8 - PubMed
  33. Nature. 2009 Apr 30;458(7242):1131-5 - PubMed
  34. J Clin Invest. 2012 Jul;122(7):2428-38 - PubMed
  35. Endocrinology. 2006 Mar;147(3):1508-16 - PubMed
  36. Biochim Biophys Acta. 1993 Aug 16;1144(1):1-16 - PubMed
  37. Best Pract Res Clin Gastroenterol. 2002 Oct;16(5):733-47 - PubMed
  38. J Hepatol. 2011 Jun;54(6):1230-6 - PubMed
  39. Horm Metab Res. 1992 Jul;24(7):322-5 - PubMed
  40. Am J Physiol Cell Physiol. 2010 Apr;298(4):C893-9 - PubMed
  41. Biochem Soc Trans. 1992 Feb;20(1):59S - PubMed
  42. Biochem J. 1963 Mar;86:408-28 - PubMed
  43. Clin Sci (Lond). 2004 Jun;106(6):635-43 - PubMed
  44. Exp Biol Med (Maywood). 2008 May;233(5):549-57 - PubMed
  45. J Hepatol. 2009 Aug;51(2):363-70 - PubMed
  46. Mol Cell Endocrinol. 1992 Aug;86(3):143-8 - PubMed
  47. Int J Mol Med. 2010 Apr;25(4):505-12 - PubMed
  48. Thyroid. 2002 Jun;12(6):459-66 - PubMed
  49. Endocr Rev. 2010 Apr;31(2):139-70 - PubMed
  50. Mol Cell Endocrinol. 2003 Dec 31;213(1):1-11 - PubMed
  51. Proc Soc Exp Biol Med. 1994 Dec;207(3):260-7 - PubMed
  52. Cell Metab. 2010 Jun 9;11(6):467-78 - PubMed
  53. Biochim Biophys Acta. 2007 Sep;1771(9):1216-25 - PubMed
  54. J Biol Regul Homeost Agents. 2011 Oct-Dec;25(4):655-60 - PubMed
  55. J Biol Chem. 2003 Mar 7;278(10):7964-72 - PubMed
  56. Endocrinology. 2005 Sep;146(9):3959-66 - PubMed
  57. Nucl Recept Signal. 2010 Apr 16;8:e002 - PubMed
  58. Nat Med. 2004 Jun;10(6):638-42 - PubMed
  59. Biochim Biophys Acta. 2009 Jun;1791(6):494-500 - PubMed
  60. J Biol Chem. 1993 Jul 15;268(20):14850-60 - PubMed
  61. J Endocrinol. 1996 May;149(2):319-25 - PubMed
  62. Am J Transl Res. 2010 Jan 01;2(1):95-104 - PubMed
  63. Am J Physiol Endocrinol Metab. 2012 Jun 1;302(11):E1419-30 - PubMed
  64. Am J Physiol. 1999 May;276(5):C1014-24 - PubMed
  65. Nat Med. 2004 Apr;10(4):355-61 - PubMed
  66. Arch Biochem Biophys. 1995 Nov 10;323(2):404-8 - PubMed
  67. J Clin Invest. 2005 May;115(5):1343-51 - PubMed
  68. J Lipid Res. 2010 Mar;51(3):468-71 - PubMed
  69. FASEB J. 2005 Sep;19(11):1552-4 - PubMed
  70. Int J Obes Relat Metab Disord. 2000 Jun;24 Suppl 2:S109-12 - PubMed
  71. Mol Biosyst. 2010 Nov;6(11):2256-71 - PubMed

Publication Types