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Belloso WH, de Paz Sierra M, Navarro M, et al. Impaired Urine Dilution Capability in HIV Stable Patients. Int J Nephrol. 2014;2014:381985doi: 10.1155/2014/381985.
Belloso, W. H., de Paz Sierra, M., Navarro, M., Sanchez, M. L., Perelsztein, A. G., & Musso, C. G. (2014). Impaired Urine Dilution Capability in HIV Stable Patients. International journal of nephrology, 2014381985. https://doi.org/10.1155/2014/381985
Belloso, Waldo H, et al. "Impaired Urine Dilution Capability in HIV Stable Patients." International journal of nephrology vol. 2014 (2014): 381985. doi: https://doi.org/10.1155/2014/381985
Belloso WH, de Paz Sierra M, Navarro M, Sanchez ML, Perelsztein AG, Musso CG. Impaired Urine Dilution Capability in HIV Stable Patients. Int J Nephrol. 2014;2014:381985. doi: 10.1155/2014/381985. Epub 2014 Mar 31. PMID: 24800076; PMCID: PMC3988737.
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Int J Nephrol. 2014;2014:381985. doi: 10.1155/2014/381985. Epub 2014 Mar 31.

Impaired Urine Dilution Capability in HIV Stable Patients.

International journal of nephrology

Waldo H Belloso, Mariana de Paz Sierra, Matilde Navarro, Marisa L Sanchez, Ariel G Perelsztein, Carlos G Musso

Affiliations

  1. Infectious Diseases Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Peron 4190, 1181 ACH Buenos Aires, Argentina.
  2. Renal Physiology Section, Nephrology Service, Hospital Italiano de Buenos Aires, Peron 4190, 1181 ACH Buenos Aires, Argentina.

PMID: 24800076 PMCID: PMC3988737 DOI: 10.1155/2014/381985

Abstract

Renal disease is a well-recognized complication among patients with HIV infection. Viral infection itself and the use of some antiretroviral drugs contribute to this condition. The thick ascending limb of Henle's loop (TALH) is the tubule segment where free water clearance is generated, determining along with glomerular filtration rate the kidney's ability to dilute urine. Objective. We analyzed the function of the proximal tubule and TALH in patients with HIV infection receiving or not tenofovir-containing antiretroviral treatment in comparison with healthy seronegative controls, by applying a tubular physiological test, hyposaline infusion test (Chaimowitz' test). Material & Methods. Chaimowitz' test was performed on 20 HIV positive volunteers who had normal renal functional parameters. The control group included 10 healthy volunteers. Results. After the test, both HIV groups had a significant reduction of serum sodium and osmolarity compared with the control group. Free water clearance was lower and urine osmolarity was higher in both HIV+ groups. Proximal tubular function was normal in both studied groups. Conclusion. The present study documented that proximal tubule sodium reabsorption was preserved while free water clearance and maximal urine dilution capability were reduced in stable HIV patients treated or not with tenofovir.

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