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Vetrivelan R, Saper CB, Fuller PM. Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions. Nat Sci Sleep. 2014;6:57-63doi: 10.2147/NSS.S53132.
Vetrivelan, R., Saper, C. B., & Fuller, P. M. (2014). Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions. Nature and science of sleep, 657-63. https://doi.org/10.2147/NSS.S53132
Vetrivelan, Ramalingam, et al. "Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions." Nature and science of sleep vol. 6 (2014): 57-63. doi: https://doi.org/10.2147/NSS.S53132
Vetrivelan R, Saper CB, Fuller PM. Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions. Nat Sci Sleep. 2014 May 02;6:57-63. doi: 10.2147/NSS.S53132. eCollection 2014. PMID: 24833927; PMCID: PMC4014362.
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Nat Sci Sleep. 2014 May 02;6:57-63. doi: 10.2147/NSS.S53132. eCollection 2014.

Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions.

Nature and science of sleep

Ramalingam Vetrivelan, Clifford B Saper, Patrick M Fuller

Affiliations

  1. Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA.

PMID: 24833927 PMCID: PMC4014362 DOI: 10.2147/NSS.S53132

Abstract

Armodafinil is the pharmacologically active R-enantiomer of modafinil, a widely prescribed wake-promoting agent used to treat several sleep-related disorders including excessive daytime sleepiness associated with narcolepsy, shift work sleep disorder, and obstructive sleep apnea/hypopnea syndrome. Remarkably, however, the neuronal circuitry through which modafinil exerts its wake-promoting effects remains unresolved. In the present study, we sought to determine if the wake-promoting effects of armodafinil are mediated, at least in part, by inhibiting the sleep-promoting neurons of the ventrolateral preoptic (VLPO) nucleus. To do so, we measured changes in waking following intraperitoneal administration of armodafinil (200 mg/kg) or the psychostimulant methamphetamine (1 mg/kg) in rats with cell-body specific lesion of the VLPO. Rats with histologically confirmed lesions of the VLPO demonstrated a sustained increase in wakefulness at baseline, but the increase in wakefulness following administration of both armodafinil and methamphetamine was similar to that of intact animals. These data suggest that armodafinil increases wakefulness by mechanisms that extend beyond inhibition of VLPO neurons.

Keywords: EEG; methamphetamine; orexin-saporin; sleep

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