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Al-Rasheed NM, Al-Rasheed NM, Faddah LM, et al. Potential impact of silymarin in combination with chlorogenic acid and/or melatonin in combating cardiomyopathy induced by carbon tetrachloride. Saudi J Biol Sci. 2013;21(3):265-74doi: 10.1016/j.sjbs.2013.09.006.
Al-Rasheed, N. M., Al-Rasheed, N. M., Faddah, L. M., Mohamed, A. M., Mohammad, R. A., & Al-Amin, M. (2014). Potential impact of silymarin in combination with chlorogenic acid and/or melatonin in combating cardiomyopathy induced by carbon tetrachloride. Saudi journal of biological sciences, 21(3), 265-74. https://doi.org/10.1016/j.sjbs.2013.09.006
Al-Rasheed, Nouf M, et al. "Potential impact of silymarin in combination with chlorogenic acid and/or melatonin in combating cardiomyopathy induced by carbon tetrachloride." Saudi journal of biological sciences vol. 21,3 (2014): 265-74. doi: https://doi.org/10.1016/j.sjbs.2013.09.006
Al-Rasheed NM, Al-Rasheed NM, Faddah LM, Mohamed AM, Mohammad RA, Al-Amin M. Potential impact of silymarin in combination with chlorogenic acid and/or melatonin in combating cardiomyopathy induced by carbon tetrachloride. Saudi J Biol Sci. 2014 Jul;21(3):265-74. doi: 10.1016/j.sjbs.2013.09.006. Epub 2013 Sep 17. PMID: 24955012; PMCID: PMC4061402.
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Saudi J Biol Sci. 2014 Jul;21(3):265-74. doi: 10.1016/j.sjbs.2013.09.006. Epub 2013 Sep 17.

Potential impact of silymarin in combination with chlorogenic acid and/or melatonin in combating cardiomyopathy induced by carbon tetrachloride.

Saudi journal of biological sciences

Nouf M Al-Rasheed, Nawal M Al-Rasheed, L M Faddah, Azza M Mohamed, Raeesa A Mohammad, Maha Al-Amin

Affiliations

  1. Pharmacology Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
  2. Biochemistry Department, Faculty of Science for Girls, King Abdulaziz University, P.O Box 51459, Jeddah 21453, Saudi Arabia ; Theraputic Chemistry Department, National Research Center, Dokki, Egypt.
  3. Anatomy Department-Faculty of Medicine-King Saud University, Riyadh, Saudi Arabia.

PMID: 24955012 PMCID: PMC4061402 DOI: 10.1016/j.sjbs.2013.09.006

Abstract

The aim of this study was to investigate the effective role of silymarin either alone or in combination with chlorogenic acid and/or melatonin against the toxic impact of carbon tetrachloride (CCl4) induced cardiac infarction. CCl4 (l.2 ml/kg body weight) was administered as a single dose intraperitoneally. The results revealed that the administration of silymarin alone or in combination with chlorogenic acid (CGA) and/or melatonin for 21 consecutive days, 24 h after CCl4 injection to rats, markedly ameliorated the increases in serum markers of cardiac infarction, including troponin T and creatine kinase-MB (CK-MB), as well as increases in the pro-inflammatory biomarkers, including interleukin-6 (IL-6), interferon-γ (IFN-γ) in serum and tumor necrosis factor-α (TNF-α) and C-reactive protein in cardiac tissue compared to CCl4 intoxicated rats. The used agents also successfully modulated the alteration in vascular endothelial growth factor (VEGF) in serum and the oxidative DNA damage and the increase in the apoptosis marker caspase 3 in cardiac tissue in response to CCl4 toxicity. The present biochemical results are supported by histo-pathological examination. The current results proved that treatment with silymarin in combination with CGA and melatonin was the most effective one in ameliorating the toxicity of CCl4 induced cardiac damage and this may support the use of this combination as an effective drug to treat cardiac damage induced by toxic agents.

Keywords: CCl4; Cardiac damage; Inflammatory biomarkers; Silymarin

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