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Tang X, Luo YX, Chen HZ, et al. Mitochondria, endothelial cell function, and vascular diseases. Front Physiol. 2014;5:175doi: 10.3389/fphys.2014.00175.
Tang, X., Luo, Y. X., Chen, H. Z., & Liu, D. P. (2014). Mitochondria, endothelial cell function, and vascular diseases. Frontiers in physiology, 5175. https://doi.org/10.3389/fphys.2014.00175
Tang, Xiaoqiang, et al. "Mitochondria, endothelial cell function, and vascular diseases." Frontiers in physiology vol. 5 (2014): 175. doi: https://doi.org/10.3389/fphys.2014.00175
Tang X, Luo YX, Chen HZ, Liu DP. Mitochondria, endothelial cell function, and vascular diseases. Front Physiol. 2014 May 06;5:175. doi: 10.3389/fphys.2014.00175. eCollection 2014. PMID: 24834056; PMCID: PMC4018556.
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Front Physiol. 2014 May 06;5:175. doi: 10.3389/fphys.2014.00175. eCollection 2014.

Mitochondria, endothelial cell function, and vascular diseases.

Frontiers in physiology

Xiaoqiang Tang, Yu-Xuan Luo, Hou-Zao Chen, De-Pei Liu

Affiliations

  1. State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing, China.

PMID: 24834056 PMCID: PMC4018556 DOI: 10.3389/fphys.2014.00175

Abstract

Mitochondria are perhaps the most sophisticated and dynamic responsive sensing systems in eukaryotic cells. The role of mitochondria goes beyond their capacity to create molecular fuel and includes the generation of reactive oxygen species, the regulation of calcium, and the activation of cell death. In endothelial cells, mitochondria have a profound impact on cellular function under both healthy and diseased conditions. In this review, we summarize the basic functions of mitochondria in endothelial cells and discuss the roles of mitochondria in endothelial dysfunction and vascular diseases, including atherosclerosis, diabetic vascular dysfunction, pulmonary artery hypertension, and hypertension. Finally, the potential therapeutic strategies to improve mitochondrial function in endothelial cells and vascular diseases are also discussed, with a focus on mitochondrial-targeted antioxidants and calorie restriction.

Keywords: antioxidants; atherosclerosis; caloric restriction; diabetes mellitus; endothelial cell; hypertension; mitochondria; pulmonary artery hypertension

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