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Zajdenverg L, Rodacki M, Faria JP, et al. Precocious markers of cardiovascular risk and vascular damage in apparently healthy women with previous gestational diabetes. Diabetol Metab Syndr. 2014;6:63doi: 10.1186/1758-5996-6-63.
Zajdenverg, L., Rodacki, M., Faria, J. P., Pires, M. L., Oliveira, J. E., & Halfoun, V. L. (2014). Precocious markers of cardiovascular risk and vascular damage in apparently healthy women with previous gestational diabetes. Diabetology & metabolic syndrome, 663. https://doi.org/10.1186/1758-5996-6-63
Zajdenverg, Lenita, et al. "Precocious markers of cardiovascular risk and vascular damage in apparently healthy women with previous gestational diabetes." Diabetology & metabolic syndrome vol. 6 (2014): 63. doi: https://doi.org/10.1186/1758-5996-6-63
Zajdenverg L, Rodacki M, Faria JP, Pires ML, Oliveira JE, Halfoun VL. Precocious markers of cardiovascular risk and vascular damage in apparently healthy women with previous gestational diabetes. Diabetol Metab Syndr. 2014 May 26;6:63. doi: 10.1186/1758-5996-6-63. eCollection 2014. PMID: 24955136; PMCID: PMC4064263.
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Diabetol Metab Syndr. 2014 May 26;6:63. doi: 10.1186/1758-5996-6-63. eCollection 2014.

Precocious markers of cardiovascular risk and vascular damage in apparently healthy women with previous gestational diabetes.

Diabetology & metabolic syndrome

Lenita Zajdenverg, Melanie Rodacki, Janaina Polo Faria, Maria Lúcia Elias Pires, José Egídio Paulo Oliveira, Vera Lúcia Castro Halfoun

Affiliations

  1. Nutrology and Diabetes Section, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

PMID: 24955136 PMCID: PMC4064263 DOI: 10.1186/1758-5996-6-63

Abstract

UNLABELLED: Previous gestational diabetes mellitus (pGDM) indicates future risk for type 2 diabetes (T2DM). Insulin resistance (IR) may precede T2DM in many years and is associated with an increased risk for cardiovascular diseases.

AIM: This study aims to identify endothelial dysfunction and cardiovascular risk factors in women with pGDM.

METHODS: This cross-sectional analysis included 45 non diabetic women, 20 pGDM and 25 controls, at least one year after delivery. Body mass index (BMI), abdominal circumference (AC), blood pressure, serum lipids, liver enzymes, uric acid, nonesterified fatty acids, C-reactive protein and plasma glucose, insulin, fibrinogen and plasminogen activator inhibitor 1 were measured. HOMA IR and β were calculated. Pre and post induced ischemia videocapillaroscopy was performed in hand nailfold to evaluate microvascular morphologic aspect and functional response.

RESULTS: AC and fasting glucose were significantly higher in pGDM (p = 0.01 and p = 0.002 respectively). Women with pGDM and BMI < 25 kg/m(2) had significantly higher levels of fasting insulin and HOMA IR than controls (p = 0.008 and 0.05 respectively). Abnormal morphologic findings were more frequent and papillae rectification were 3.3 times more prevalent in pGDM (p = 0.003). Other microvascular parameters did not differ between groups.

CONCLUSION: Cardiovascular risk factors and a microcirculation abnormality (papillae rectification) were significantly increased in young non-diabetic women with pGDM.

Keywords: Cardiovascular risk; Gestational diabetes; Microangiopathy

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