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Yang S, Emiliani V, Tang CM. The kinetics of multibranch integration on the dendritic arbor of CA1 pyramidal neurons. Front Cell Neurosci. 2014;8:127doi: 10.3389/fncel.2014.00127.
Yang, S., Emiliani, V., & Tang, C. M. (2014). The kinetics of multibranch integration on the dendritic arbor of CA1 pyramidal neurons. Frontiers in cellular neuroscience, 8127. https://doi.org/10.3389/fncel.2014.00127
Yang, Sunggu, et al. "The kinetics of multibranch integration on the dendritic arbor of CA1 pyramidal neurons." Frontiers in cellular neuroscience vol. 8 (2014): 127. doi: https://doi.org/10.3389/fncel.2014.00127
Yang S, Emiliani V, Tang CM. The kinetics of multibranch integration on the dendritic arbor of CA1 pyramidal neurons. Front Cell Neurosci. 2014 May 13;8:127. doi: 10.3389/fncel.2014.00127. eCollection 2014. PMID: 24860429; PMCID: PMC4026731.
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Front Cell Neurosci. 2014 May 13;8:127. doi: 10.3389/fncel.2014.00127. eCollection 2014.

The kinetics of multibranch integration on the dendritic arbor of CA1 pyramidal neurons.

Frontiers in cellular neuroscience

Sunggu Yang, Valentina Emiliani, Cha-Min Tang

Affiliations

  1. Department of Neurology, University of Maryland School of Medicine, Baltimore MD, USA.
  2. Wavefront-engineering Microscopy Group, Neurophotonics Laboratory, CNRS UMR 8250, Paris Descartes University Paris, France.
  3. Department of Neurology, University of Maryland School of Medicine, Baltimore MD, USA ; Baltimore Veterans Adminstration Medical Center, Baltimore MD, USA.

PMID: 24860429 PMCID: PMC4026731 DOI: 10.3389/fncel.2014.00127

Abstract

The process by which synaptic inputs separated in time and space are integrated by the dendritic arbor to produce a sequence of action potentials is among the most fundamental signal transformations that takes place within the central nervous system. Some aspects of this complex process, such as integration at the level of individual dendritic branches, have been extensively studied. But other aspects, such as how inputs from multiple branches are combined, and the kinetics of that integration have not been systematically examined. Using a 3D digital holographic photolysis technique to overcome the challenges posed by the complexities of the 3D anatomy of the dendritic arbor of CA1 pyramidal neurons for conventional photolysis, we show that integration on a single dendrite is fundamentally different from that on multiple dendrites. Multibranch integration occurring at oblique and basal dendrites allows somatic action potential firing of the cell to faithfully follow the driving stimuli over a significantly wider frequency range than what is possible with single branch integration. However, multibranch integration requires greater input strength to drive the somatic action potentials. This tradeoff between sensitivity and temporal precision may explain the puzzling report of the predominance of multibranch, rather than single branch, integration from in vivo recordings during presentation of visual stimuli.

Keywords: 3D digital holography; multibranch integration

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