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Lukovic D, Moreno-Manzano V, Klabusay M, et al. Non-coding RNAs in pluripotency and neural differentiation of human pluripotent stem cells. Front Genet. 2014;5:132doi: 10.3389/fgene.2014.00132.
Lukovic, D., Moreno-Manzano, V., Klabusay, M., Stojkovic, M., Bhattacharya, S. S., & Erceg, S. (2014). Non-coding RNAs in pluripotency and neural differentiation of human pluripotent stem cells. Frontiers in genetics, 5132. https://doi.org/10.3389/fgene.2014.00132
Lukovic, Dunja, et al. "Non-coding RNAs in pluripotency and neural differentiation of human pluripotent stem cells." Frontiers in genetics vol. 5 (2014): 132. doi: https://doi.org/10.3389/fgene.2014.00132
Lukovic D, Moreno-Manzano V, Klabusay M, Stojkovic M, Bhattacharya SS, Erceg S. Non-coding RNAs in pluripotency and neural differentiation of human pluripotent stem cells. Front Genet. 2014 May 14;5:132. doi: 10.3389/fgene.2014.00132. eCollection 2014. PMID: 24860598; PMCID: PMC4030195.
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Front Genet. 2014 May 14;5:132. doi: 10.3389/fgene.2014.00132. eCollection 2014.

Non-coding RNAs in pluripotency and neural differentiation of human pluripotent stem cells.

Frontiers in genetics

Dunja Lukovic, Victoria Moreno-Manzano, Martin Klabusay, Miodrag Stojkovic, Shomi S Bhattacharya, Slaven Erceg

Affiliations

  1. Retina Group, Cell therapy and Regenerative Medicine, Centro Andaluz de Biología Molecular y Medicina Regenerativa Sevilla, Spain.
  2. Neuronal and Tissue Regeneration Lab, Centro de Investigación Príncipe Felipe Valencia, Spain.
  3. Integrated Center of Cellular Therapy and Regenerative Medicine - International Clinical Research Center, St. Anne's University Hospital Brno Brno, Czech Republic.
  4. Spebo Medical Leskovac, Serbia ; Human Genetics Department, Faculty of Medical Sciences, University of Kragujevac Kragujevac, Serbia.

PMID: 24860598 PMCID: PMC4030195 DOI: 10.3389/fgene.2014.00132

Abstract

Several studies have demonstrated the important role of non-coding RNAs as regulators of posttranscriptional processes, including stem cells self-renewal and neural differentiation. Human embryonic stem cells (hESCs) and induced pluripotent stem cells (ihPSCs) show enormous potential in regenerative medicine due to their capacity to differentiate to virtually any type of cells of human body. Deciphering the role of non-coding RNAs in pluripotency, self-renewal and neural differentiation will reveal new molecular mechanisms involved in induction and maintenances of pluripotent state as well as triggering these cells toward clinically relevant cells for transplantation. In this brief review we will summarize recently published studies which reveal the role of non-coding RNAs in pluripotency and neural differentiation of hESCs and ihPSC.

Keywords: differentiation; human embryonic stem cells; non-coding RNA; pluripotency; pluripotent stem cells

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