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Shackelford R, Pollen M, Vora M, et al. Malignant Melanoma with Concurrent BRAF E586K and NRAS Q81K Mutations. Case Rep Oncol. 2014;7(2):297-300doi: 10.1159/000362788.
Shackelford, R., Pollen, M., Vora, M., Jusion, T. T., Cotelingam, J., & Nair, B. (2014). Malignant Melanoma with Concurrent BRAF E586K and NRAS Q81K Mutations. Case reports in oncology, 7(2), 297-300. https://doi.org/10.1159/000362788
Shackelford, Rodney, et al. "Malignant Melanoma with Concurrent BRAF E586K and NRAS Q81K Mutations." Case reports in oncology vol. 7,2 (2014): 297-300. doi: https://doi.org/10.1159/000362788
Shackelford R, Pollen M, Vora M, Jusion TT, Cotelingam J, Nair B. Malignant Melanoma with Concurrent BRAF E586K and NRAS Q81K Mutations. Case Rep Oncol. 2014 May 08;7(2):297-300. doi: 10.1159/000362788. eCollection 2014 May. PMID: 24926260; PMCID: PMC4035678.
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Case Rep Oncol. 2014 May 08;7(2):297-300. doi: 10.1159/000362788. eCollection 2014 May.

Malignant Melanoma with Concurrent BRAF E586K and NRAS Q81K Mutations.

Case reports in oncology

Rodney Shackelford, Maressa Pollen, Moise Vora, Tamara T Jusion, James Cotelingam, Binu Nair

Affiliations

  1. Department of PathologyClinical Pathology Molecular Pathology Consultative Services, La., USA.
  2. Clinical Pathology Molecular Pathology Consultative Services, La., USA.
  3. Hematology/Oncology, LSU Health Shreveport, Shreveport, La., USA.

PMID: 24926260 PMCID: PMC4035678 DOI: 10.1159/000362788

Abstract

Cutaneous melanoma is an aggressive malignant tumor of melanocytes which accounts for 80% of skin cancer-related deaths. A number of driver mutations have been identified in melanoma, with the mutually exclusive BRAF V600E and NRAS Q61A mutations together accounting for roughly 70% of mutations. Simultaneous BRAF V600E and NRAS Q61A mutations in melanoma are rare, with evidence suggesting that up to 2.9% (2/69) of primary cutaneous melanomas carry both mutations. Here we describe a 42-year-old man with concurrent BRAF E586K and NRAS Q81K driver mutations. To our knowledge, this is the first description of these driver mutations occurring simultaneously in primary cutaneous melanoma.

Keywords: Concurrent BRAF E586K and NRAS Q81K mutations; Cutaneous melanoma; Skin cancer

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