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Domis MJ, Moritz ML. Red man syndrome following intraperitoneal vancomycin in a child with peritonitis. Front Pediatr. 2014;2:55doi: 10.3389/fped.2014.00055.
Domis, M. J., & Moritz, M. L. (2014). Red man syndrome following intraperitoneal vancomycin in a child with peritonitis. Frontiers in pediatrics, 255. https://doi.org/10.3389/fped.2014.00055
Domis, Melissa J, and Moritz, Michael L. "Red man syndrome following intraperitoneal vancomycin in a child with peritonitis." Frontiers in pediatrics vol. 2 (2014): 55. doi: https://doi.org/10.3389/fped.2014.00055
Domis MJ, Moritz ML. Red man syndrome following intraperitoneal vancomycin in a child with peritonitis. Front Pediatr. 2014 Jun 05;2:55. doi: 10.3389/fped.2014.00055. eCollection 2014. PMID: 24926475; PMCID: PMC4046263.
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Front Pediatr. 2014 Jun 05;2:55. doi: 10.3389/fped.2014.00055. eCollection 2014.

Red man syndrome following intraperitoneal vancomycin in a child with peritonitis.

Frontiers in pediatrics

Melissa J Domis, Michael L Moritz

Affiliations

  1. Department of Pediatrics, Cleveland Clinic Children's , Cleveland, OH , USA.
  2. Division of Nephrology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine , Pittsburgh, PA , USA.

PMID: 24926475 PMCID: PMC4046263 DOI: 10.3389/fped.2014.00055

Abstract

Red man syndrome (RMS) has frequently been reported to occur with intravenous vancomycin therapy. However, there have been few reports of this complication during intraperitoneal (IP) treatment with vancomycin. This report describes an 11-year-old boy with end stage renal disease who developed RMS 45 min into the initial loading dose of IP vancomycin for the treatment of bacterial peritonitis with a vancomycin level of 38.8 mcg/mL. The patient developed this adverse reaction despite appropriate initial loading dose per ISPD guidelines for continuous treatment (1000 mg/L). This case emphasizes the importance of monitoring for adverse reactions of vancomycin therapy, and raises dosing considerations that differ slightly from the currently recommended ISPD guidelines for IP vancomycin treatment in the treatment of bacterial peritonitis.

Keywords: adverse reaction; peritoneal dialysis; peritonitis; red man syndrome; vancomycin

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