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Peñuelas I, Gambhir SS. Imaging studies for evaluating gene therapy in translational research. Drug Discov Today Technol. 2005;2(4):335-43doi: 10.1016/j.ddtec.2005.11.006.
Peñuelas, I., & Gambhir, S. S. (2005). Imaging studies for evaluating gene therapy in translational research. Drug discovery today. Technologies, 2(4), 335-43. https://doi.org/10.1016/j.ddtec.2005.11.006
Peñuelas, Iván, and Gambhir, Sanjiv S. "Imaging studies for evaluating gene therapy in translational research." Drug discovery today. Technologies vol. 2,4 (2005): 335-43. doi: https://doi.org/10.1016/j.ddtec.2005.11.006
Peñuelas I, Gambhir SS. Imaging studies for evaluating gene therapy in translational research. Drug Discov Today Technol. 2005;2(4):335-43. doi: 10.1016/j.ddtec.2005.11.006. PMID: 24982010.
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Drug Discov Today Technol. 2005;2(4):335-43. doi: 10.1016/j.ddtec.2005.11.006.

Imaging studies for evaluating gene therapy in translational research.

Drug discovery today. Technologies

Iván Peñuelas, Sanjiv S Gambhir

Affiliations

  1. MicroPET Research Unit, CIMA-CUN, University of Navarra, Pamplona, Spain. Electronic address:[email protected].
  2. Molecular Imaging Program at Stanford (MIPS), Departments of Radiology and Bioengineering, Bio-X Program, Stanford University, Stanford, CA, USA.

PMID: 24982010 DOI: 10.1016/j.ddtec.2005.11.006

Abstract

Molecular imaging of gene expression in living subjects is leading to significant advances in the field of gene therapy. Three different technologies have been utilized for monitoring gene expression: optical imaging, radionuclide imaging and magnetic resonance imaging. In the present review, we focus on the latest developments including multimodality approaches and recent imaging of human gene therapy to noninvasively determine the location(s), magnitude and time-variation of gene therapy. Continued development should lead to greater use of these technologies in gene therapy and also help to shed light towards optimizing gene therapy in preclinical models and in the clinical setting.:

© 2005 Elsevier Ltd . All rights reserved.

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