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Peymen K, Watteyne J, Frooninckx L, et al. The FMRFamide-Like Peptide Family in Nematodes. Front Endocrinol (Lausanne). 2014;5:90doi: 10.3389/fendo.2014.00090.
Peymen, K., Watteyne, J., Frooninckx, L., Schoofs, L., & Beets, I. (2014). The FMRFamide-Like Peptide Family in Nematodes. Frontiers in endocrinology, 590. https://doi.org/10.3389/fendo.2014.00090
Peymen, Katleen, et al. "The FMRFamide-Like Peptide Family in Nematodes." Frontiers in endocrinology vol. 5 (2014): 90. doi: https://doi.org/10.3389/fendo.2014.00090
Peymen K, Watteyne J, Frooninckx L, Schoofs L, Beets I. The FMRFamide-Like Peptide Family in Nematodes. Front Endocrinol (Lausanne). 2014 Jun 16;5:90. doi: 10.3389/fendo.2014.00090. eCollection 2014. PMID: 24982652; PMCID: PMC4058706.
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Front Endocrinol (Lausanne). 2014 Jun 16;5:90. doi: 10.3389/fendo.2014.00090. eCollection 2014.

The FMRFamide-Like Peptide Family in Nematodes.

Frontiers in endocrinology

Katleen Peymen, Jan Watteyne, Lotte Frooninckx, Liliane Schoofs, Isabel Beets

Affiliations

  1. Functional Genomics and Proteomics Group, Department of Biology, KU Leuven , Leuven , Belgium.

PMID: 24982652 PMCID: PMC4058706 DOI: 10.3389/fendo.2014.00090

Abstract

In the three decades since the FMRFamide peptide was isolated from the mollusk Macrocallista nimbosa, structurally similar peptides sharing a C-terminal RFamide motif have been identified across the animal kingdom. FMRFamide-like peptides (FLPs) represent the largest known family of neuropeptides in invertebrates. In the phylum Nematoda, at least 32 flp-genes are classified, making the FLP system of nematodes unusually complex. The diversity of the nematode FLP complement is most extensively mapped in Caenorhabditis elegans, where over 70 FLPs have been predicted. FLPs have shown to be expressed in the majority of the 302 C. elegans neurons including interneurons, sensory neurons, and motor neurons. The vast expression of FLPs is reflected in the broad functional repertoire of nematode FLP signaling, including neuroendocrine and neuromodulatory effects on locomotory activity, reproduction, feeding, and behavior. In contrast to the many identified nematode FLPs, only few peptides have been assigned a receptor and there is the need to clarify the pathway components and working mechanisms of the FLP signaling network. Here, we review the diversity, distribution, and functions of FLPs in nematodes.

Keywords: C. elegans; FMRFamide-like peptides; G protein-coupled receptor; feeding behavior; nematodes; neuropeptide; reproduction

References

  1. Int J Parasitol. 2005 Sep;35(10):1043-60 - PubMed
  2. Genetics. 2000 Mar;154(3):1181-92 - PubMed
  3. Invert Neurosci. 1995 Dec;1(3):255-65 - PubMed
  4. Nature. 2005 Jul 28;436(7050):510-7 - PubMed
  5. Neurobiol Learn Mem. 2009 Sep;92(2):139-46 - PubMed
  6. Nature. 2004 Jul 15;430(6997):317-22 - PubMed
  7. Curr Drug Targets. 2012 Feb;13(2):230-46 - PubMed
  8. Science. 2009 Jan 16;323(5912):382-4 - PubMed
  9. Invert Neurosci. 2008 Jun;8(2):91-100 - PubMed
  10. Nature. 2007 Nov 1;450(7166):63-70 - PubMed
  11. Learn Mem. 2010 Mar 24;17(4):191-201 - PubMed
  12. Science. 1991 Mar 8;251(4998):1243-6 - PubMed
  13. Parasitology. 1994 Sep;109 ( Pt 3):351-6 - PubMed
  14. Int J Parasitol. 2009 Nov;39(13):1503-16 - PubMed
  15. Biochem Biophys Res Commun. 1999 Jan 8;254(1):222-30 - PubMed
  16. PLoS Biol. 2006 Sep;4(9):e274 - PubMed
  17. Curr Top Med Chem. 2002 Jul;2(7):733-58 - PubMed
  18. J Comp Neurol. 2005 Aug 8;488(4):396-413 - PubMed
  19. Nature. 2002 Oct 31;419(6910):899-903 - PubMed
  20. Neuron. 2012 Oct 4;76(1):82-97 - PubMed
  21. Front Endocrinol (Lausanne). 2012 Dec 21;3:167 - PubMed
  22. Curr Biol. 2003 Sep 30;13(19):1715-20 - PubMed
  23. PLoS One. 2013 Nov 06;8(11):e80603 - PubMed
  24. Acta Biol Hung. 1995;46(2-4):195-204 - PubMed
  25. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7321-6 - PubMed
  26. Neuron. 2012 Aug 23;75(4):585-92 - PubMed
  27. Trends Parasitol. 2006 Aug;22(8):385-96 - PubMed
  28. J Biol Chem. 2003 Oct 24;278(43):42115-20 - PubMed
  29. Biochem Biophys Res Commun. 1994 Apr 29;200(2):973-80 - PubMed
  30. Ann N Y Acad Sci. 2009 Apr;1163:60-74 - PubMed
  31. Genetics. 2011 May;188(1):91-103 - PubMed
  32. Biochem Biophys Res Commun. 2001 Sep 7;286(5):1170-6 - PubMed
  33. Neuron. 1989 May;2(5):1465-73 - PubMed
  34. Parasitology. 1998 Mar;116 ( Pt 3):277-87 - PubMed
  35. Br J Pharmacol. 2007 Jul;151(6):888-99 - PubMed
  36. Nat Rev Neurosci. 2004 Jul;5(7):565-75 - PubMed
  37. Nature. 1995 Dec 14;378(6558):730-3 - PubMed
  38. Parasitology. 1996;113 Suppl:S97-117 - PubMed
  39. Mol Neurobiol. 2000 Feb-Apr;21(1-2):35-56 - PubMed
  40. Peptides. 1996;17(3):381-7 - PubMed
  41. PLoS Comput Biol. 2005 Nov;1(6):e64 - PubMed
  42. J Comp Neurol. 2011 Jun 1;519(8):1546-61 - PubMed
  43. Peptides. 2001 Jan;22(1):7-23 - PubMed
  44. J Comp Neurol. 2010 Mar 15;518(6):896-910 - PubMed
  45. J Proteome Res. 2011 Jul 1;10(7):3098-106 - PubMed
  46. Nat Neurosci. 2013 Oct;16(10):1461-7 - PubMed
  47. Proc Natl Acad Sci U S A. 2013 May 28;110(22):E2028-37 - PubMed
  48. Invert Neurosci. 2009 Dec;9(3-4):111-53 - PubMed
  49. Fed Proc. 1983 Jan;42(1):82-6 - PubMed
  50. Nat Biotechnol. 2008 Aug;26(8):909-15 - PubMed
  51. Brain Res Mol Brain Res. 1998 Jul 15;58(1-2):103-11 - PubMed
  52. J Comp Neurol. 2004 Aug 2;475(4):540-50 - PubMed
  53. Mol Biochem Parasitol. 2005 Jan;139(1):51-64 - PubMed
  54. Biochem Biophys Res Commun. 2005 May 13;330(3):967-74 - PubMed
  55. Parasitology. 2005;131 Suppl:S129-42 - PubMed
  56. Mol Biochem Parasitol. 2001 Sep 3;116(2):199-208 - PubMed
  57. Cell. 2009 Oct 16;139(2):416-27 - PubMed
  58. Nat Neurosci. 2010 May;13(5):615-21 - PubMed
  59. Peptides. 1992 Mar-Apr;13(2):209-14 - PubMed
  60. Br J Pharmacol. 1997 Feb;120(3):379-86 - PubMed
  61. Peptides. 1997;18(7):929-35 - PubMed
  62. Neuron. 2006 Sep 7;51(5):613-25 - PubMed
  63. Nature. 2009 Apr 30;458(7242):1171-5 - PubMed
  64. Eur J Biochem. 1994 Apr 1;221(1):269-75 - PubMed
  65. WormBook. 2013 Aug 13;:1-106 - PubMed
  66. Int J Parasitol. 2002 Dec 19;32(14):1765-71 - PubMed
  67. J Neurosci. 2003 Aug 13;23(19):7317-25 - PubMed
  68. Parasitol Today. 1996 Sep;12(9):351-7 - PubMed
  69. J Neurosci. 2013 Jun 5;33(23):9675-83 - PubMed
  70. Neuron. 2004 Jun 10;42(5):731-43 - PubMed
  71. Neuron. 2013 Jun 5;78(5):869-80 - PubMed
  72. Cell. 2002 Nov 15;111(4):483-93 - PubMed
  73. J Neurosci. 1985 Apr;5(4):956-64 - PubMed
  74. J Comp Neurol. 1989 Jun 15;284(3):374-88 - PubMed
  75. Parasitology. 1995 Sep;111 ( Pt 3):379-84 - PubMed
  76. J Neurobiol. 2005 Dec;65(3):304-19 - PubMed
  77. Ann N Y Acad Sci. 1999;897:253-63 - PubMed
  78. ACS Chem Biol. 2008 Sep 19;3(9):530-41 - PubMed
  79. Peptides. 1993 Mar-Apr;14(2):331-8 - PubMed
  80. PLoS Pathog. 2011 Sep;7(9):e1002219 - PubMed
  81. ACS Chem Neurosci. 2013 Mar 20;4(3):418-34 - PubMed
  82. Nat Neurosci. 2010 May;13(5):610-4 - PubMed
  83. Curr Biol. 2006 Apr 4;16(7):649-59 - PubMed
  84. Front Endocrinol (Lausanne). 2012 Aug 09;3:93 - PubMed
  85. Int J Parasitol. 2011 Jul;41(8):881-94 - PubMed
  86. Nature. 2002 Oct 31;419(6910):925-9 - PubMed
  87. Science. 2008 Oct 17;322(5900):460-4 - PubMed
  88. Genes Dev. 2007 Jul 1;21(13):1653-74 - PubMed
  89. Biochem Biophys Res Commun. 1997 Feb 24;231(3):591-5 - PubMed
  90. J Neurochem. 2007 Jul;102(1):246-60 - PubMed
  91. Nat Neurosci. 2008 Oct;11(10):1168-76 - PubMed
  92. J Neurosci. 1992 Jun;12(6):2356-61 - PubMed
  93. Learn Mem. 2013 Jan 16;20(2):103-8 - PubMed
  94. Cell. 1998 Sep 4;94(5):679-89 - PubMed
  95. Int J Parasitol. 2003 Jul 30;33(8):859-76 - PubMed
  96. Science. 1977 Aug 12;197(4304):670-1 - PubMed
  97. Science. 1998 Sep 11;281(5383):1686-90 - PubMed
  98. PLoS Genet. 2013 May;9(5):e1003472 - PubMed
  99. Philos Trans R Soc Lond B Biol Sci. 1986 Nov 12;314(1165):1-340 - PubMed
  100. Genetics. 1974 May;77(1):71-94 - PubMed
  101. PLoS Pathog. 2013 Feb;9(2):e1003169 - PubMed
  102. J Neurosci. 2006 Nov 8;26(45):11582-7 - PubMed
  103. Nature. 1993 Jul 22;364(6435):337-41 - PubMed
  104. Adv Exp Med Biol. 2010;692:49-77 - PubMed
  105. Mol Interv. 2008 Dec;8(6):284-93 - PubMed
  106. Bioessays. 2012 Jun;34(6):458-65 - PubMed
  107. J Comp Neurol. 1992 Feb 8;316(2):251-60 - PubMed
  108. Peptides. 2011 Jun;32(6):1335-55 - PubMed
  109. Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8038-43 - PubMed
  110. Science. 2012 Oct 26;338(6106):543-5 - PubMed
  111. PLoS One. 2012;7(5):e37831 - PubMed
  112. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3184-91 - PubMed
  113. Rapid Commun Mass Spectrom. 2003;17(24):2693-8 - PubMed
  114. Biochem Biophys Res Commun. 1998 Jul 20;248(2):422-5 - PubMed
  115. J Neurochem. 2006 Sep;98(6):1999-2012 - PubMed
  116. Mol Biochem Parasitol. 2011 Nov;180(1):27-34 - PubMed
  117. Behav Brain Res. 1990 Feb 12;37(1):89-92 - PubMed
  118. Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15512-7 - PubMed
  119. ACS Chem Neurosci. 2010 Jul 21;1(7):505-519 - PubMed
  120. Genetics. 1993 Apr;133(4):897-917 - PubMed
  121. Protein Pept Lett. 2013 Jun;20(6):647-70 - PubMed
  122. FEBS Lett. 2004 Aug 27;573(1-3):55-60 - PubMed
  123. Biochem Biophys Res Commun. 2005 Sep 16;335(1):76-86 - PubMed
  124. Science. 1998 Dec 11;282(5396):2012-8 - PubMed
  125. Worm. 2012 Jan 1;1(1):42-50 - PubMed
  126. FASEB J. 2007 Apr;21(4):1233-43 - PubMed
  127. Int J Parasitol. 2002 Aug;32(9):1095-105 - PubMed
  128. Peptides. 2009 Mar;30(3):449-57 - PubMed
  129. J Neurosci. 2007 Jul 4;27(27):7174-82 - PubMed
  130. Adv Exp Med Biol. 2010;692:98-137 - PubMed
  131. Mol Biochem Parasitol. 2000 Nov;111(1):185-97 - PubMed
  132. Int J Parasitol Drugs Drug Resist. 2012 Nov 15;3:1-7 - PubMed
  133. Brain Res. 1999 Nov 27;848(1-2):26-34 - PubMed
  134. Annu Rev Neurosci. 1984;7:223-55 - PubMed
  135. Neuropeptides. 2008 Feb;42(1):1-18 - PubMed
  136. Annu Rev Neurosci. 1998;21:279-308 - PubMed
  137. Nat Neurosci. 2003 Nov;6(11):1178-85 - PubMed
  138. Pharmacogenomics. 2004 Sep;5(6):657-72 - PubMed
  139. Philos Trans R Soc Lond B Biol Sci. 1976 Aug 10;275(938):299-325 - PubMed
  140. Nature. 1995 Nov 2;378(6552):82-5 - PubMed
  141. Int J Parasitol. 2010 Jan;40(1):91-100 - PubMed
  142. Genetics. 1983 Aug;104(4):619-47 - PubMed
  143. Cell Metab. 2009 Apr;9(4):375-85 - PubMed
  144. Peptides. 1993 May-Jun;14(3):423-30 - PubMed
  145. Eur J Pharmacol. 2002 Dec 5;456(1-3):11-7 - PubMed
  146. Brain Res Mol Brain Res. 1994 Jul;24(1-4):238-46 - PubMed
  147. Br J Pharmacol. 2001 Mar;132(6):1247-54 - PubMed
  148. J Neurobiol. 2001 Nov 15;49(3):235-44 - PubMed
  149. Prog Neurobiol. 2007 May;82(1):33-55 - PubMed
  150. Science. 1993 Jul 30;261(5121):617-9 - PubMed
  151. Parasitology. 1991;102 Suppl:S107-16 - PubMed
  152. J Biol Chem. 2003 Sep 5;278(36):33724-9 - PubMed
  153. EuPA Open Proteom. 2014 Apr 19;3:262-272 - PubMed
  154. J Helminthol. 2010 Sep;84(3):253-65 - PubMed
  155. J Endocrinol. 2007 Jan;192(1):3-15 - PubMed
  156. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8702-7 - PubMed
  157. Peptides. 1999;20(8):999-1019 - PubMed
  158. Trends Pharmacol Sci. 2007 Aug;28(8):431-7 - PubMed
  159. J Comp Neurol. 2007 Jun 10;502(5):872-82 - PubMed
  160. Biopolymers. 2008;90(3):339-48 - PubMed
  161. Annu Rev Neurosci. 2005;28:451-501 - PubMed
  162. Peptides. 2006 Jun;27(6):1291-6 - PubMed
  163. Exp Physiol. 2004 May;89(3):229-35 - PubMed
  164. Horm Behav. 2006 Dec;50(5):655-66 - PubMed
  165. Parasitology. 2005;131 Suppl:S169-77 - PubMed
  166. Int J Parasitol. 2003 Feb;33(2):199-208 - PubMed
  167. Ann N Y Acad Sci. 1999;897:228-38 - PubMed
  168. Curr Biol. 2005 May 24;15(10):905-17 - PubMed

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