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Verboket PE, Borovinskaya O, Meyer N, et al. A new microfluidics-based droplet dispenser for ICPMS. Anal Chem. 2014;86(12):6012-8doi: 10.1021/ac501149a.
Verboket, P. E., Borovinskaya, O., Meyer, N., Günther, D., & Dittrich, P. S. (2014). A new microfluidics-based droplet dispenser for ICPMS. Analytical chemistry, 86(12), 6012-8. https://doi.org/10.1021/ac501149a
Verboket, Pascal E, et al. "A new microfluidics-based droplet dispenser for ICPMS." Analytical chemistry vol. 86,12 (2014): 6012-8. doi: https://doi.org/10.1021/ac501149a
Verboket PE, Borovinskaya O, Meyer N, Günther D, Dittrich PS. A new microfluidics-based droplet dispenser for ICPMS. Anal Chem. 2014 Jun 17;86(12):6012-8. doi: 10.1021/ac501149a. Epub 2014 May 31. PMID: 24805360; PMCID: PMC4063494.
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Anal Chem. 2014 Jun 17;86(12):6012-8. doi: 10.1021/ac501149a. Epub 2014 May 31.

A new microfluidics-based droplet dispenser for ICPMS.

Analytical chemistry

Pascal E Verboket, Olga Borovinskaya, Nicole Meyer, Detlef Günther, Petra S Dittrich

Affiliations

  1. Laboratory of Organic Chemistry, and ‡Laboratory of Inorganic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich , 8093 Zurich Switzerland.

PMID: 24805360 PMCID: PMC4063494 DOI: 10.1021/ac501149a

Abstract

In this work, a novel droplet microfluidic sample introduction system for inductively coupled plasma mass spectrometry (ICPMS) is proposed and characterized. The cheap and disposable microfluidic chip generates droplets of an aqueous sample in a stream of perfluorohexane (PFH), which is also used to eject them as a liquid jet. The aqueous droplets remain intact during the ejection and can be transported into the ICP with >50% efficiency. The transport is realized via a custom-built system, which includes a membrane desolvator necessary for the PFH vapor removal. The introduction system presented here can generate highly monodisperse droplets in the size range of 40-60 μm at frequencies from 90 to 300 Hz. These droplets produced very stable signals with a relative standard deviation (RSD) comparable to the one achieved with a commercial droplet dispenser. Using the current system, samples with a total volume of <1 μL can be analyzed. Moreover, the capabilities of the setup for introduction and quantitative elemental analysis of single cells were described using a test system of bovine red blood cells. In the future, other modules of the modern microfludics can be integrated in the chip, such as on-chip sample pretreatment or parallel introduction of different samples.

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