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Hariman A, Alex C, Heroux A, et al. Incidence of fractures after cardiac and lung transplantation: a single center experience. J Osteoporos. 2014;2014:573041doi: 10.1155/2014/573041.
Hariman, A., Alex, C., Heroux, A., & Camacho, P. (2014). Incidence of fractures after cardiac and lung transplantation: a single center experience. Journal of osteoporosis, 2014573041. https://doi.org/10.1155/2014/573041
Hariman, Aileen, et al. "Incidence of fractures after cardiac and lung transplantation: a single center experience." Journal of osteoporosis vol. 2014 (2014): 573041. doi: https://doi.org/10.1155/2014/573041
Hariman A, Alex C, Heroux A, Camacho P. Incidence of fractures after cardiac and lung transplantation: a single center experience. J Osteoporos. 2014;2014:573041. doi: 10.1155/2014/573041. Epub 2014 Apr 22. PMID: 24864223; PMCID: PMC4016909.
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J Osteoporos. 2014;2014:573041. doi: 10.1155/2014/573041. Epub 2014 Apr 22.

Incidence of fractures after cardiac and lung transplantation: a single center experience.

Journal of osteoporosis

Aileen Hariman, Charles Alex, Alain Heroux, Pauline Camacho

Affiliations

  1. Department of Endocrinology, Loyola University Medical Center, Maywood, IL 60153, USA.
  2. Department of Pulmonology/Critical Care, Advocate Christ Medical Center, Oak Lawn, IL 60453, USA.
  3. Department of Cardiology, Loyola University Medical Center, Maywood, IL 60153, USA.

PMID: 24864223 PMCID: PMC4016909 DOI: 10.1155/2014/573041

Abstract

Osteoporotic fractures are well-known complications of organ transplantation. Fracture rates up to 35% have been previously reported following heart and lung transplantations. Our institutional pretransplant protocols include DXA scans, vitamin D screening, and appropriate antiresorptive therapy. We aimed to assess the incidence of fragility fractures following cardiac or lung transplantation. In a retrospective study 210 electronic medical records of patients who underwent LT (110 men, 100 women) and 105 HT (88 men, 17 women) between 2005 and 2010 were analyzed. Both clinical and radiographic fractures were recorded. DXA scans were obtained immediately after transplant. 17 out of 210 LT patients (8.0%) had fractures after transplantation and 9 out of 105 HT patients (8.6%) had fractures. The median time to the first fracture was 12 months and the mean time was 18 months for both LT and HT. In the HT recipients, the median femoral neck T score was statistically lower in the fracture group versus the nonfracture group. Similar results were seen in the LT patients. Conclusion. Our findings demonstrate a much lower incidence of fractures in heart and lung transplant recipients in comparison with earlier reports. Comprehensive bone care and early initiation of antiresorptive therapy are possible contributors to these improved outcomes.

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