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Fan X, Jin WY, Wang YT. The NMDA receptor complex: a multifunctional machine at the glutamatergic synapse. Front Cell Neurosci. 2014;8:160doi: 10.3389/fncel.2014.00160.
Fan, X., Jin, W. Y., & Wang, Y. T. (2014). The NMDA receptor complex: a multifunctional machine at the glutamatergic synapse. Frontiers in cellular neuroscience, 8160. https://doi.org/10.3389/fncel.2014.00160
Fan, Xuelai, et al. "The NMDA receptor complex: a multifunctional machine at the glutamatergic synapse." Frontiers in cellular neuroscience vol. 8 (2014): 160. doi: https://doi.org/10.3389/fncel.2014.00160
Fan X, Jin WY, Wang YT. The NMDA receptor complex: a multifunctional machine at the glutamatergic synapse. Front Cell Neurosci. 2014 Jun 10;8:160. doi: 10.3389/fncel.2014.00160. eCollection 2014. PMID: 24959120; PMCID: PMC4051310.
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Front Cell Neurosci. 2014 Jun 10;8:160. doi: 10.3389/fncel.2014.00160. eCollection 2014.

The NMDA receptor complex: a multifunctional machine at the glutamatergic synapse.

Frontiers in cellular neuroscience

Xuelai Fan, Wu Yang Jin, Yu Tian Wang

Affiliations

  1. Brain Research Centre and Department of Medicine, Vancouver Coastal Health Research Institute, University of British Columbia Vancouver, BC, Canada.

PMID: 24959120 PMCID: PMC4051310 DOI: 10.3389/fncel.2014.00160

Abstract

The N-methyl-D-aspartate receptors (NMDARs) are part of a large multiprotein complex at the glutamatergic synapse. The assembly of NMDARs with synaptic proteins offers a means to regulate NMDAR channel properties and receptor trafficking, and couples NMDAR activation to distinct intracellular signaling pathways, thus contributing to the versatility of NMDAR functions. Receptor-protein interactions at the synapse provide a dynamic and powerful mechanism for regulating synaptic efficacy, but can also contribute to NMDAR overactivation-induced excitotoxicity and cellular damage under pathological conditions. An emerging concept is that by understanding the mechanisms and functions of disease-specific protein-protein interactions in the NMDAR complex, we may be able to develop novel therapies based on protein-NMDAR interactions for the treatment of brain diseases in which NMDAR dysfunction is at the root of their pathogenesis.

Keywords: NMDA receptors; dopamine receptors; excitotoxicity; ion channel complex; protein-protein interaction; signaling pathways; synaptic plasticity

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