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Sandholm J, Tuomela J, Kauppila JH, et al. Hypoxia regulates Toll-like receptor-9 expression and invasive function in human brain cancer cells in vitro. Oncol Lett. 2014;8(1):266-274doi: 10.3892/ol.2014.2095.
Sandholm, J., Tuomela, J., Kauppila, J. H., Harris, K. W., Graves, D., & Selander, K. S. (2014). Hypoxia regulates Toll-like receptor-9 expression and invasive function in human brain cancer cells in vitro. Oncology letters, 8(1), 266-274. https://doi.org/10.3892/ol.2014.2095
Sandholm, Jouko, et al. "Hypoxia regulates Toll-like receptor-9 expression and invasive function in human brain cancer cells in vitro." Oncology letters vol. 8,1 (2014): 266-274. doi: https://doi.org/10.3892/ol.2014.2095
Sandholm J, Tuomela J, Kauppila JH, Harris KW, Graves D, Selander KS. Hypoxia regulates Toll-like receptor-9 expression and invasive function in human brain cancer cells in vitro. Oncol Lett. 2014 Jul;8(1):266-274. doi: 10.3892/ol.2014.2095. Epub 2014 Apr 25. PMID: 24959259; PMCID: PMC4063648.
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Oncol Lett. 2014 Jul;8(1):266-274. doi: 10.3892/ol.2014.2095. Epub 2014 Apr 25.

Hypoxia regulates Toll-like receptor-9 expression and invasive function in human brain cancer cells in vitro.

Oncology letters

Jouko Sandholm, Johanna Tuomela, Joonas H Kauppila, Kevin W Harris, David Graves, Katri S Selander

Affiliations

  1. Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  2. Department of Pathology, Oulu University Hospital, Oulu 90029, Finland ; Department of Surgery, Oulu University Hospital, Oulu 90029, Finland ; Department of Anatomy and Cell Biology, University of Oulu, Oulu 90570, Finland.
  3. Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA ; Birmingham Veterans Affairs Medical Center, Birmingham, AL 35233, USA.
  4. Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

PMID: 24959259 PMCID: PMC4063648 DOI: 10.3892/ol.2014.2095

Abstract

Toll-like receptor-9 (TLR9) is a cellular DNA sensor of the innate immune system. TLR9 is widely expressed in a number of tumors, including brain cancer; however, little is known regarding its regulation and involvement in cancer pathophysiology. The present study demonstrated that hypoxia upregulates and downregulates TLR9 expression in human brain cancer cells

Keywords: Toll-like receptor-9; brain cancer; hypoxia; invasion

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