Display options
Cite
Sinai C, Hirvikoski T, Nordström AL, et al. Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder. Eur J Psychotraumatol. 2014;5doi: 10.3402/ejpt.v5.23911.
Sinai, C., Hirvikoski, T., Nordström, A. L., Nordström, P., Nilsonne, A., Wilczek, A., Asberg, M., & Jokinen, J. (2014). Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder. European journal of psychotraumatology, 5. https://doi.org/10.3402/ejpt.v5.23911
Sinai, Cave, et al. "Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder." European journal of psychotraumatology vol. 5 (2014). doi: https://doi.org/10.3402/ejpt.v5.23911
Sinai C, Hirvikoski T, Nordström AL, Nordström P, Nilsonne A, Wilczek A, Asberg M, Jokinen J. Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder. Eur J Psychotraumatol. 2014 May 16;5. doi: 10.3402/ejpt.v5.23911. eCollection 2014. PMID: 24959326; PMCID: PMC4024607.
Copy Download .nbib Format: NLM
Share it on

Eur J Psychotraumatol. 2014 May 16;5. doi: 10.3402/ejpt.v5.23911. eCollection 2014.

Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder.

European journal of psychotraumatology

Cave Sinai, Tatja Hirvikoski, Anna-Lena Nordström, Peter Nordström, Asa Nilsonne, Alexander Wilczek, Marie Asberg, Jussi Jokinen

Affiliations

  1. Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden.
  2. Department of Children's and Women's Health, Center for Neurodevelopmental Disorders at Karolinska Institutet (KIND), Stockholm, Sweden.
  3. Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden.

PMID: 24959326 PMCID: PMC4024607 DOI: 10.3402/ejpt.v5.23911

Abstract

BACKGROUND: A relationship between exposure to sexual violence and thyroid hormone alterations has been observed among women with posttraumatic stress disorder (PTSD). Women with borderline personality disorder (BPD) report a high estimate of childhood trauma.

OBJECTIVE: The aim of the present study was to assess relationships between thyroid hormone measures and exposure to violence in childhood in women with BPD.

METHOD: A total of 92 clinically euthyroid women with BPD (53% with comorbid PTSD) diagnosis and at least two prior suicide attempts were assessed with the Karolinska Interpersonal Violence Scales (KIVS). The KIVS contains four subscales with concrete examples of exposure to violence and expressed violent behavior in childhood (aged 6-14 years) and during adult life (15 years or older). Baseline thyroid function was evaluated by measuring plasma free and bound triiodothyronine (FT3 and T3), thyroxine (FT4 and T4), and thyroid-stimulating hormone (TSH) with immunoassays. The FT3/FT4 ratio was used to estimate peripheral deiodination. Plasma cortisol was also assessed.

RESULTS: Sixty-seven percent of patients reported medium high or high level of exposure to interpersonal violence as a child. The FT3/FT4 ratio showed a significant negative correlation with exposure to violence as a child. Patients with PTSD had significantly higher plasma cortisol levels. An ad hoc analysis revealed that the correlation between KIVS exposure to interpersonal violence as a child and FT3/FT4 ratio was significant only in patients with comorbid PTSD. Altered thyroid activity, especially FT3/FT4, levels was associated with exposure to violence in childhood in women with BPD.

CONCLUSION: Severe childhood trauma-related stress may promote lasting altered thyroid levels and/or contribute to the development of psychopathology associated with BPD traits or PTSD.

Keywords: HPT axis; borderline personality disorder; childhood adverse events; childhood maltreatment; interpersonal violence; stress; thyroid hormones; trauma

References

  1. Compr Psychiatry. 1994 Jul-Aug;35(4):301-5 - PubMed
  2. Psychol Med. 2000 Jan;30(1):41-52 - PubMed
  3. Endocrinology. 2012 Sep;153(9):4128-35 - PubMed
  4. Am J Psychiatry. 2003 Nov;160(11):2018-24 - PubMed
  5. Eur Arch Psychiatry Clin Neurosci. 2008 Dec;258(8):456-62 - PubMed
  6. Aviat Space Environ Med. 1978 Jan;49(1 Pt 1):58-61 - PubMed
  7. Psychosom Med. 1999 Mar-Apr;61(2):131-8 - PubMed
  8. Br J Psychiatry. 2007 Nov;191:387-92 - PubMed
  9. J Clin Psychiatry. 2008 Apr;69(4):584-96 - PubMed
  10. Psychoneuroendocrinology. 2006 Nov;31(10):1220-30 - PubMed
  11. Child Abuse Negl. 2006 Jun;30(6):585-8 - PubMed
  12. Br J Psychiatry. 2002 Jun;180:536-42 - PubMed
  13. J Nerv Ment Dis. 2002 Aug;190(8):510-8 - PubMed
  14. Am J Psychiatry. 1997 Aug;154(8):1101-6 - PubMed
  15. J Child Psychol Psychiatry. 2000 Jan;41(1):97-116 - PubMed
  16. Psychosom Med. 2004 May-Jun;66(3):403-10 - PubMed
  17. Child Abuse Negl. 2004 Aug;28(8):863-75 - PubMed
  18. J Clin Psychiatry. 2008 Apr;69(4):533-45 - PubMed
  19. Wien Klin Wochenschr. 2004 Jun 30;116(11-12):385-90 - PubMed
  20. Arch Gen Psychiatry. 1994 Aug;51(8):629-41 - PubMed
  21. J Clin Psychiatry. 2010 Aug;71(8):1025-32 - PubMed
  22. Clin Psychol Rev. 2012 Jun;32(4):301-15 - PubMed
  23. Am J Psychiatry. 1997 Dec;154(12):1715-9 - PubMed
  24. Am J Psychiatry. 2004 Nov;161(11):2108-14 - PubMed
  25. J Child Sex Abus. 2011 Sep;20(5):548-87 - PubMed
  26. Mil Med. 2002 Oct;167(10):846-9 - PubMed
  27. Am J Psychiatry. 2013 Oct;170(10):1114-33 - PubMed
  28. Nat Rev Endocrinol. 2009 Apr;5(4):211-8 - PubMed
  29. Eur Psychiatry. 2009 Jan;24(1):57-62 - PubMed
  30. Harv Rev Psychiatry. 2009;17(3):167-83 - PubMed
  31. Am J Psychiatry. 2004 Jul;161(7):1296-8 - PubMed
  32. Biol Psychiatry. 2005 May 15;57(10):1186-92 - PubMed

Publication Types