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Rahimzadeh P, Imani F, Faiz SH, et al. Effect of intravenous methylprednisolone on pain after intertrochanteric femoral fracture surgery. J Clin Diagn Res. 2014;8(4):GC01-4doi: 10.7860/JCDR/2014/8232.4305.
Rahimzadeh, P., Imani, F., Faiz, S. H., Nikoubakht, N., & Sayarifard, A. (2014). Effect of intravenous methylprednisolone on pain after intertrochanteric femoral fracture surgery. Journal of clinical and diagnostic research : JCDR, 8(4), GC01-4. https://doi.org/10.7860/JCDR/2014/8232.4305
Rahimzadeh, Poupak, et al. "Effect of intravenous methylprednisolone on pain after intertrochanteric femoral fracture surgery." Journal of clinical and diagnostic research : JCDR vol. 8,4 (2014): GC01-4. doi: https://doi.org/10.7860/JCDR/2014/8232.4305
Rahimzadeh P, Imani F, Faiz SH, Nikoubakht N, Sayarifard A. Effect of intravenous methylprednisolone on pain after intertrochanteric femoral fracture surgery. J Clin Diagn Res. 2014 Apr;8(4):GC01-4. doi: 10.7860/JCDR/2014/8232.4305. Epub 2014 Apr 15. PMID: 24959459; PMCID: PMC4064860.
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J Clin Diagn Res. 2014 Apr;8(4):GC01-4. doi: 10.7860/JCDR/2014/8232.4305. Epub 2014 Apr 15.

Effect of intravenous methylprednisolone on pain after intertrochanteric femoral fracture surgery.

Journal of clinical and diagnostic research : JCDR

Poupak Rahimzadeh, Farnad Imani, Seyed Hamid Reza Faiz, Nasim Nikoubakht, Azadeh Sayarifard

Affiliations

  1. Assistant Professor, Anesthesiologist, Department of Anesthesiology and Pain Medicine, Rasoul-Akram Medical Center , Iran. University of Medical Sciences Tehran, Iran .
  2. Anesthesiologist, Department of Anesthesiology and Pain Medicine, Rasoul-Akram Medical Center , Iran. University of Medical Sciences, Tehran, Iran .
  3. Resident of Anesthesiology, Department of Anesthesiology and Pain Medicine, Rasoul-Akram Medical Center , Iran. University of Medical Sciences, Tehran, Iran .
  4. Assistant Professor, Preventive and Community Medicine Specialist, Community Based Participatory Research Center, Iranian Institute for Reduction of High-Risk Behaviors , Tehran University of Medical Sciences, Tehran, Iran .

PMID: 24959459 PMCID: PMC4064860 DOI: 10.7860/JCDR/2014/8232.4305

Abstract

BACKGROUND: Pain after surgery is one of the major problems in patients with intertrochanteric fracture. This study investigates administration of single-dose Methylprednisolone prior to surgery with the goal of reducing Post-operative pain.

MATERIALS AND METHODS: The study was a Double Blind Randomized Clinical Trial. Eighty two patients with stable intertrochanteric unilateral fracture were selected and divided into two groups: one received Methylprednisolone (MP) 125 mg and the other received placebo. Pain was evaluated at rest and 45° flexion of the hip in times 4, 6, 8, 12, 24, 36, and 48 hours and during walking in times 24, 36, and 48 hours after the surgery. Post-operative nausea, vomiting and fatigue and changes in C - reactive protein (CRP) levels before and after the surgery were also recorded.

RESULTS: Pain at rest, 45° flexion of the hip and during walking after the surgery was significantly lower in the MP group compared to the control group (p < 0.001). Fatigue (p = 0.002) and changes in CRP (p=0.001) were significantly lower in MP group. Incidence of nausea, vomiting (p = 0.37) and opioid consumption (p = 0.49) were not significantly different between the two groups.

CONCLUSION: Single-dose methylprednisolone 125 mg (IV) can reduce Post-operative pain in patients with intertrochanteric fracture undergoing elective surgery.

Keywords: Intertrochanteric fractures; Methylprednisolone; Post-operative pain

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