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Murakami Y, Tabata K, Sugita A, et al. Multidisciplinary treatment including systemic chemotherapy for a malignant phyllodes tumour of the prostate. Can Urol Assoc J. 2014;8(3):E263-5doi: 10.5489/cuaj.1648.
Murakami, Y., Tabata, K., Sugita, A., Mochizuki, K., Maeyama, R., Okazaki, M., Nishi, M., Matsumoto, K., Fujita, T., Satoh, T., Jiang, S. X., Saegusa, M., & Iwamura, M. (2014). Multidisciplinary treatment including systemic chemotherapy for a malignant phyllodes tumour of the prostate. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 8(3), E263-5. https://doi.org/10.5489/cuaj.1648
Murakami, Yasukiyo, et al. "Multidisciplinary treatment including systemic chemotherapy for a malignant phyllodes tumour of the prostate." Canadian Urological Association journal = Journal de l'Association des urologues du Canada vol. 8,3 (2014): E263-5. doi: https://doi.org/10.5489/cuaj.1648
Murakami Y, Tabata K, Sugita A, Mochizuki K, Maeyama R, Okazaki M, Nishi M, Matsumoto K, Fujita T, Satoh T, Jiang SX, Saegusa M, Iwamura M. Multidisciplinary treatment including systemic chemotherapy for a malignant phyllodes tumour of the prostate. Can Urol Assoc J. 2014 Mar;8(3):E263-5. doi: 10.5489/cuaj.1648. PMID: 24839496; PMCID: PMC4001657.
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Can Urol Assoc J. 2014 Mar;8(3):E263-5. doi: 10.5489/cuaj.1648.

Multidisciplinary treatment including systemic chemotherapy for a malignant phyllodes tumour of the prostate.

Canadian Urological Association journal = Journal de l'Association des urologues du Canada

Yasukiyo Murakami, Ken-Ichi Tabata, Atsushi Sugita, Kohei Mochizuki, Ryota Maeyama, Miyoko Okazaki, Morihiro Nishi, Kazumasa Matsumoto, Tetsuo Fujita, Takefumi Satoh, Shi-Xu Jiang, Makoto Saegusa, Masatsugu Iwamura

Affiliations

  1. Department of Urology, Kitasato University School of Medicine, Japan;
  2. Department of Pharmacology, Kitasato University School of Medicine, Japan;
  3. Department of Pathology, Kitasato University School of Medicine, Japan.

PMID: 24839496 PMCID: PMC4001657 DOI: 10.5489/cuaj.1648

Abstract

A 22-year-old man was referred to our hospital with macroscopic hematuria and consistent anal pain. Magnetic resonance imaging revealed an enlarged prostate tumour invading the bladder and rectum. A biopsy revealed an unclassified spindle cell sarcoma. Subsequently, radical cystoprostatectomy and resection of the rectum were performed. A histopathological examination revealed a prostatic malignant phyllodes tumour with a negative surgical margin. However, a local recurrence was identified 2 months after surgery. Induction therapy included 4 cycles of systemic chemotherapy comprising etoposide with ifosfamide and cisplatin. Although a partial response was observed at the local site, lung metastasis developed. Second-line chemotherapy with ifosfamide and doxorubicin with radiotherapy to the pelvis was administered and led to complete regression; however, its efficacy was transient. Although additional chemotherapy was administered, the patient eventually died due to the rapidly growing, recurrent tumour.

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