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Kato T, Addo KK, Nartey N, et al. First Susceptibility Testing of Mycobacterium tuberculosis for Second-line Anti-tuberculosis Drugs in Ghana. Trop Med Health. 2014;42(1):53-5doi: 10.2149/tmh.2013-16.
Kato, T., Addo, K. K., Nartey, N., Nyarko, A. K., Bonsu, F. A., & Mitarai, S. (2014). First Susceptibility Testing of Mycobacterium tuberculosis for Second-line Anti-tuberculosis Drugs in Ghana. Tropical medicine and health, 42(1), 53-5. https://doi.org/10.2149/tmh.2013-16
Kato, Tomoko, et al. "First Susceptibility Testing of Mycobacterium tuberculosis for Second-line Anti-tuberculosis Drugs in Ghana." Tropical medicine and health vol. 42,1 (2014): 53-5. doi: https://doi.org/10.2149/tmh.2013-16
Kato T, Addo KK, Nartey N, Nyarko AK, Bonsu FA, Mitarai S. First Susceptibility Testing of Mycobacterium tuberculosis for Second-line Anti-tuberculosis Drugs in Ghana. Trop Med Health. 2014 Mar;42(1):53-5. doi: 10.2149/tmh.2013-16. Epub 2014 Feb 04. PMID: 24808747; PMCID: PMC3965846.
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Trop Med Health. 2014 Mar;42(1):53-5. doi: 10.2149/tmh.2013-16. Epub 2014 Feb 04.

First Susceptibility Testing of Mycobacterium tuberculosis for Second-line Anti-tuberculosis Drugs in Ghana.

Tropical medicine and health

Tomoko Kato, Kennedy Kwasi Addo, Naomi Nartey, Alexander Kwadwo Nyarko, Frank Adae Bonsu, Satoshi Mitarai

Affiliations

  1. Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-tuberculosis Association, Tokyo, Japan.
  2. Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
  3. National Tuberculosis Programme, Ghana Health Service, Ghana.

PMID: 24808747 PMCID: PMC3965846 DOI: 10.2149/tmh.2013-16

Abstract

We performed drug susceptibility testing on first- and second-line drugs in Mycobacterium tuberculosis (M. tuberculosis) for the first time in Ghana to obtain preliminary data on drug-resistant tuberculosis. Of 21 isolates (4 new cases and 17 treated cases), 5 (23.8%) were multi-drug resistant tuberculosis (MDR-TB) and 19 (90.5%) were resistant to at least one drug, but no extensively drug-resistant TB (XDR-TB) was identified. Since the target patients were Category II, IV or smear positive at follow-up microscopy, it is understandable that there were many drug-resistant TB cases. Six isolates were resistant to one or two second-line drugs, but the second-line drugs were not approved in Ghana. It is considered that the bacilli were imported from abroad. Preventing the import of drug-resistant TB bacilli is probably one of best ways to control TB in Ghana.

Keywords: Drug susceptibility testing; Ghana; MDR/XDR-TB; second-line drugs

References

  1. Ghana Med J. 2010 Jun;44(2):42-6 - PubMed
  2. Bull World Health Organ. 2012 Feb 1;90(2):111-119D - PubMed

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