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Stone LL, Grande A, Low WC. Neural repair and neuroprotection with stem cells in ischemic stroke. Brain Sci. 2013;3(2):599-614doi: 10.3390/brainsci3020599.
Stone, L. L., Grande, A., & Low, W. C. (2013). Neural repair and neuroprotection with stem cells in ischemic stroke. Brain sciences, 3(2), 599-614. https://doi.org/10.3390/brainsci3020599
Stone, Laura L, et al. "Neural repair and neuroprotection with stem cells in ischemic stroke." Brain sciences vol. 3,2 (2013): 599-614. doi: https://doi.org/10.3390/brainsci3020599
Stone LL, Grande A, Low WC. Neural repair and neuroprotection with stem cells in ischemic stroke. Brain Sci. 2013 Apr 23;3(2):599-614. doi: 10.3390/brainsci3020599. PMID: 24961416; PMCID: PMC4061842.
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Brain Sci. 2013 Apr 23;3(2):599-614. doi: 10.3390/brainsci3020599.

Neural repair and neuroprotection with stem cells in ischemic stroke.

Brain sciences

Laura L Stone, Andy Grande, Walter C Low

Affiliations

  1. Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA. [email protected].
  2. Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA. [email protected].
  3. Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA. [email protected].

PMID: 24961416 PMCID: PMC4061842 DOI: 10.3390/brainsci3020599

Abstract

Stem cells have been touted as a potential source of cells for repair in regenerative medicine. When transplanted into the central nervous system, stem cells have been shown to differentiate into neurons and glia. Recent studies, however, have also revealed neuroprotective properties of stem cells. These studies suggest that various types of stem cells are able to protect against the loss of neurons in conditions of ischemic brain injury. In this article, we discuss the use of stem cells for ischemic stroke and the parameters under which neuroprotection can occur in the translation of stem cell therapy to the clinical setting.

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