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Menzie J, Prentice H, Wu JY. Neuroprotective Mechanisms of Taurine against Ischemic Stroke. Brain Sci. 2013;3(2):877-907doi: 10.3390/brainsci3020877.
Menzie, J., Prentice, H., & Wu, J. Y. (2013). Neuroprotective Mechanisms of Taurine against Ischemic Stroke. Brain sciences, 3(2), 877-907. https://doi.org/10.3390/brainsci3020877
Menzie, Janet, et al. "Neuroprotective Mechanisms of Taurine against Ischemic Stroke." Brain sciences vol. 3,2 (2013): 877-907. doi: https://doi.org/10.3390/brainsci3020877
Menzie J, Prentice H, Wu JY. Neuroprotective Mechanisms of Taurine against Ischemic Stroke. Brain Sci. 2013 Jun 03;3(2):877-907. doi: 10.3390/brainsci3020877. PMID: 24961429; PMCID: PMC4061860.
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Brain Sci. 2013 Jun 03;3(2):877-907. doi: 10.3390/brainsci3020877.

Neuroprotective Mechanisms of Taurine against Ischemic Stroke.

Brain sciences

Janet Menzie, Howard Prentice, Jang-Yen Wu

Affiliations

  1. Program in Integrative Biology, Florida Atlantic University, Boca Raton, FL 33431, USA. [email protected].
  2. Department of Biomedical Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA. [email protected].
  3. Program in Integrative Biology, Florida Atlantic University, Boca Raton, FL 33431, USA. [email protected].

PMID: 24961429 PMCID: PMC4061860 DOI: 10.3390/brainsci3020877

Abstract

Ischemic stroke exhibits a multiplicity of pathophysiological mechanisms. To address the diverse pathophysiological mechanisms observed in ischemic stroke investigators seek to find therapeutic strategies that are multifaceted in their action by either investigating multipotential compounds or by using a combination of compounds. Taurine, an endogenous amino acid, exhibits a plethora of physiological functions. It exhibits antioxidative properties, stabilizes membrane, functions as an osmoregulator, modulates ionic movements, reduces the level of pro-inflammators, regulates intracellular calcium concentration; all of which contributes to its neuroprotective effect. Data are accumulating that show the neuroprotective mechanisms of taurine against stroke pathophysiology. In this review, we describe the neuroprotective mechanisms employed by taurine against ischemic stroke and its use in clinical trial for ischemic stroke.

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