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Sacchetti E, Cassano GB, Penati G, et al. Paroxetine versus amitriptyline in patients with recurrent major depression: A double-blind trial. Int J Psychiatry Clin Pract. 2002;6(1):23-9doi: 10.1080/136515002753489380.
Sacchetti, E., Cassano, G. B., Penati, G., Pavan, L., Nardini, M., Casacchia, M., Pancheri, P., Muscettola, G., Faravelli, C., Aguglia, E., Nivoli, G., Ravizza, L., & Castrogiovanni, P. (2002). Paroxetine versus amitriptyline in patients with recurrent major depression: A double-blind trial. International journal of psychiatry in clinical practice, 6(1), 23-9. https://doi.org/10.1080/136515002753489380
Sacchetti, Emilio, et al. "Paroxetine versus amitriptyline in patients with recurrent major depression: A double-blind trial." International journal of psychiatry in clinical practice vol. 6,1 (2002): 23-9. doi: https://doi.org/10.1080/136515002753489380
Sacchetti E, Cassano GB, Penati G, Pavan L, Nardini M, Casacchia M, Pancheri P, Muscettola G, Faravelli C, Aguglia E, Nivoli G, Ravizza L, Castrogiovanni P. Paroxetine versus amitriptyline in patients with recurrent major depression: A double-blind trial. Int J Psychiatry Clin Pract. 2002;6(1):23-9. doi: 10.1080/136515002753489380. PMID: 24931886.
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Int J Psychiatry Clin Pract. 2002;6(1):23-9. doi: 10.1080/136515002753489380.

Paroxetine versus amitriptyline in patients with recurrent major depression: A double-blind trial.

International journal of psychiatry in clinical practice

Emilio Sacchetti, Giovanni B Cassano, Gaetano Penati, Luigi Pavan, Marcello Nardini, Massimo Casacchia, Paolo Pancheri, Giovanni Muscettola, Carlo Faravelli, Eugenio Aguglia, Giancarlo Nivoli, Luigi Ravizza, Paolo Castrogiovanni

PMID: 24931886 DOI: 10.1080/136515002753489380

Abstract

INTRODUCTION: Long-term exposure to antidepressants is required to prevent relapses and recurrences in patients with recurrent major depression. Furthermore, a good pharmacological compliance is the key to successful long-term treatment. Since the early phases of a treatment influence long-term compliance and compliance is adversely affected by poorly tolerated treatments, efficacy and tolerability of paroxetine and amitryptiline over 12 weeks were compared as an introduction to the issue of long-term compliance to these two agents.

METHOD: A 12-week, randomized, double-blind, doubledummy, parallel-group trial which involved 129 patients with recurrent major depression.

RESULTS: Both paroxetine and amitriptyline were effective in controlling the symptoms of depression, as shown by the reduction in HAMD total score and CGI severity-of-illness score at endpoint compared to baseline. There was no statistically or clinically significant difference between the two treatments in terms of efficacy. However, marked numerical differences were noted in tolerability: the percentage of patients who reported treatment-emergent adverse experiences was greater in the amitriptyline group (40.0% vs 28.1%). This difference was mainly due to anticholinergic adverse events, which were six times more frequent with amitriptyline than with paroxetine.

CONCLUSION: When compared with amitriptyline, paroxetine should allow patients with recurrent major depression to receive an equally effective treatment with a relatively lower incidence of adverse experiences.

Keywords: Amitriptyline; Clinical; Depression; Efficacy; Paroxetine; Trial

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