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Indian J Crit Care Med. 2014 Jun;18(6):399-401. doi: 10.4103/0972-5229.133939.

Management of life-threatening calcium channel blocker overdose with continuous veno-venous hemodiafiltration with charcoal hemoperfusion.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

Suneel K Garg, Pankaj K Goyal, Rahul Kumar, Deven Juneja, Alka Bhasin, Omender Singh

Affiliations

  1. Institute of Critical Care Medicine, Max Super Speciality Hospital, New Delhi, India.

PMID: 24987241 PMCID: PMC4071686 DOI: 10.4103/0972-5229.133939

Abstract

Cases of calcium channel blocker overdose reported from India are few, and although rare, they are associated with high mortality. Management includes fluids, vasopressors, calcium gluconate or chloride, glucagon infusion, and hyperinsulinemia-euglycemia therapy along with some rescue therapies tried in anecdotal reports. We report here a case of life-threatening overdose of amlodipine with shock, refractory to conventional therapies. Salvage therapy with continuous veno-venous hemodiafiltration using charcoal hemoperfusion with prior infusion of intravenous lipid emulsion resulted in a successful outcome.

Keywords: Amlodipine overdose; calcium channel blocker overdose; charcoal hemoperfusion; continuous veno-venous hemodiafiltration

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