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Vitolins MZ, Milliron BJ, Hopkins JO, et al. Weight Loss Intervention in Survivors of ER/PR-negative Breast Cancer. Clin Med Insights Womens Health. 2014;7:17-24doi: 10.4137/CMWH.S13955.
Vitolins, M. Z., Milliron, B. J., Hopkins, J. O., Fulmer, A., Lawrence, J., Melin, S., & Case, D. (2014). Weight Loss Intervention in Survivors of ER/PR-negative Breast Cancer. Clinical medicine insights. Women's health, 717-24. https://doi.org/10.4137/CMWH.S13955
Vitolins, Mara Z, et al. "Weight Loss Intervention in Survivors of ER/PR-negative Breast Cancer." Clinical medicine insights. Women's health vol. 7 (2014): 17-24. doi: https://doi.org/10.4137/CMWH.S13955
Vitolins MZ, Milliron BJ, Hopkins JO, Fulmer A, Lawrence J, Melin S, Case D. Weight Loss Intervention in Survivors of ER/PR-negative Breast Cancer. Clin Med Insights Womens Health. 2014 Jun 16;7:17-24. doi: 10.4137/CMWH.S13955. eCollection 2014. PMID: 24987274; PMCID: PMC4069035.
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Clin Med Insights Womens Health. 2014 Jun 16;7:17-24. doi: 10.4137/CMWH.S13955. eCollection 2014.

Weight Loss Intervention in Survivors of ER/PR-negative Breast Cancer.

Clinical medicine insights. Women's health

Mara Z Vitolins, Brandy-Joe Milliron, Judith O Hopkins, Artie Fulmer, Julia Lawrence, Susan Melin, Douglas Case

Affiliations

  1. Division of Public Health Sciences, Wake Forest University Health Sciences, Medical Center Blvd, Winston-Salem, NC, USA. ; Wake Forest University Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
  2. Department of Nutrition Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA USA.
  3. Derrick L. Davis Forsyth Regional Cancer Center, Winston-Salem, NC, USA.
  4. Division of Public Health Sciences, Wake Forest University Health Sciences, Medical Center Blvd, Winston-Salem, NC, USA.
  5. Wake Forest University Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, NC, USA.

PMID: 24987274 PMCID: PMC4069035 DOI: 10.4137/CMWH.S13955

Abstract

Numerous studies have found that increased body size (weight or body mass index) is a risk factor for breast cancer development, recurrence, and death. The detrimental relationship between body size and breast cancer recurrence may be more pronounced among women with estrogen receptor (ER)/progesterone receptor (PR)-negative breast cancer. Considering the limited availability of treatments, and the association between body size and recurrence, alternative treatments are needed for ER/PR-negative breast cancer survivors, particularly overweight survivors. The objective of this pilot study was to examine the feasibility of a 12-week, multi-component meal-replacement weight loss intervention among overweight or obese ER/PR-negative breast cancer survivors; and to obtain preliminary data on changes in anthropometrics, biomarkers, and health-related quality of life (QOL). The 12-week intervention included a portion-controlled diet (including meal replacements) and a multi-component intervention (including behavioral techniques, diet modification, physical activity, and social support). The goal of the intervention was to help participants lose 5% or more of their initial weight by reducing their caloric intake and increasing their physical activity (to at least 15 minutes each day). Paired t-tests assessed changes in continuous measures. Body weight was measured weekly and mixed-model regression analysis assessed change in weight over time. Nineteen ER/PR-negative breast cancer survivors with a mean age of 59 years participated in the study. All but two of the participants completed the 12-week intervention. Women lost an average of 6.3 ± 4.9 kg (P < 0.001), equivalent to 7.5% of their baseline weight. There were significant reductions in waist circumference (P = 0.001), percent fat mass (P < 0.001), total cholesterol (P = 0.026), and triglycerides (P = 0.002); and improvements in health-related QOL (P = 0.017). Findings suggested that a meal-replacement weight loss approach among ER/PR-negative breast cancer survivors was feasible and was well received.

Keywords: estrogen negative breast cancer; meal replacement; nutrition intervention; weight loss

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