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Hamza MA, Galal A, Suweilam S, et al. Local Intracoronary Eptifibatide versus Mechanical Aspiration in Patients with Acute ST-Elevation Myocardial Infarction. Int J Vasc Med. 2014;2014:294065doi: 10.1155/2014/294065.
Hamza, M. A., Galal, A., Suweilam, S., & Ismail, M. (2014). Local Intracoronary Eptifibatide versus Mechanical Aspiration in Patients with Acute ST-Elevation Myocardial Infarction. International journal of vascular medicine, 2014294065. https://doi.org/10.1155/2014/294065
Hamza, Mohamed A, et al. "Local Intracoronary Eptifibatide versus Mechanical Aspiration in Patients with Acute ST-Elevation Myocardial Infarction." International journal of vascular medicine vol. 2014 (2014): 294065. doi: https://doi.org/10.1155/2014/294065
Hamza MA, Galal A, Suweilam S, Ismail M. Local Intracoronary Eptifibatide versus Mechanical Aspiration in Patients with Acute ST-Elevation Myocardial Infarction. Int J Vasc Med. 2014;2014:294065. doi: 10.1155/2014/294065. Epub 2014 Jun 03. PMID: 24987529; PMCID: PMC4060498.
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Int J Vasc Med. 2014;2014:294065. doi: 10.1155/2014/294065. Epub 2014 Jun 03.

Local Intracoronary Eptifibatide versus Mechanical Aspiration in Patients with Acute ST-Elevation Myocardial Infarction.

International journal of vascular medicine

Mohamed A Hamza, Ayman Galal, Salwa Suweilam, Mohamed Ismail

Affiliations

  1. Ain Shams University, P.O. Box 11381, Cairo, Egypt ; Cardiology Department, Ain Shams University, Lotfy Elsayed Street, Abbaseya, P.O. Box 11381, Cairo, Egypt.
  2. Ain Shams University, P.O. Box 11381, Cairo, Egypt.

PMID: 24987529 PMCID: PMC4060498 DOI: 10.1155/2014/294065

Abstract

Objectives. We compared local delivery of intracoronary eptifibatide via perfusion catheter to thrombus aspiration in primary PCI. Background. Perfusion catheter increases local concentration of the drugs at the culprit site and prolongs their residency time. Methods. 75 patients with acute STEMI were randomized to three groups: 25 received local intracoronary eptifibatide and verapamil via perfusion catheter; 25 patients were managed by Diver CE thrombectomy device and 25 patients by primary PCI without thrombus aspiration. Primary end point was assessment of postprocedural TIMI flow, MPG, and corrected TIMI frame count (cTFC) in the culprit vessel. Results. Perfusion catheter was superior to thrombus aspiration and conventional PCI as regards MBG (68% versus 36% in Diver CE and 20% in the control arm; P value = 0.002), with shorter cTFC rates than thrombectomy and control groups (20.76 ± 4.44 versus 26.68 ± 8.40 and 28.16 ± 5.96, resp.; P = 0.001). TIMI flow was not different between the 3 groups. Eptifibatide led to less time to peak CK (13.12 hours versus 16.5 and 19.5 hours, respectively, P value = 0.001). Conclusion. Local intracoronary eptifibatide by perfusion catheter reduces thrombus burden with better results in microvascular perfusion assessed by cTFC and MBG compared to aspiration device or conventional PCI.

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