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Irfan S, Ahmad A, Guhar D, et al. Fluoroquinolone and macrolide co-resistance in clinical isolates of Campylobacter species: a 15-year study in Karachi, Pakistan. East Mediterr Health J. 2012;16(12):1226-30doi: 10.26719/2010.16.12.1226.
Irfan, S., Ahmad, A., Guhar, D., Khan, E., Malik, F., Mahmood, S., Zafar, A., Krieg, J. M., & Goldhaber, D. (2012). Fluoroquinolone and macrolide co-resistance in clinical isolates of Campylobacter species: a 15-year study in Karachi, Pakistan. Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit, 16(12), 1226-30. https://doi.org/10.26719/2010.16.12.1226
Irfan, S, et al. "Fluoroquinolone and macrolide co-resistance in clinical isolates of Campylobacter species: a 15-year study in Karachi, Pakistan." Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit vol. 16,12 (2012): 1226-30. doi: https://doi.org/10.26719/2010.16.12.1226
Irfan S, Ahmad A, Guhar D, Khan E, Malik F, Mahmood S, Zafar A, Krieg JM, Goldhaber D. Fluoroquinolone and macrolide co-resistance in clinical isolates of Campylobacter species: a 15-year study in Karachi, Pakistan. East Mediterr Health J. 2012 Dec 04;16(12):1226-30. doi: 10.26719/2010.16.12.1226. PMID: 24988396.
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East Mediterr Health J. 2012 Dec 04;16(12):1226-30. doi: 10.26719/2010.16.12.1226.

Fluoroquinolone and macrolide co-resistance in clinical isolates of Campylobacter species: a 15-year study in Karachi, Pakistan.

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit

S Irfan, A Ahmad, D Guhar, E Khan, F Malik, S Mahmood, A Zafar, Krieg, Goldhaber

Affiliations

  1. Department of Pathology & Microbiology, Aga Khan University, Karachi, Pakistan.

PMID: 24988396 DOI: 10.26719/2010.16.12.1226

Abstract

Fluoroquinolone and macrolide antibiotics are generally considered as first-line drugs for the treatment of severe campylobacteriosis. This study was conducted to analyse the trend of erythromycin and ofloxacin resistance among Campylobacter spp. isolated from stool specimens over a period of 15 years (1992-2007) at The Aga Khan University clinical laboratory in Karachi, Pakistan. A total of 83 396 stool specimens were processed, with a 14% isolation rate for enteric pathogens. The isolation rate of Campylobacter spp. was low during 1992-93 (6%-13%), peaked in 1996 (46%), then ranged from 20% to 40%. We report a rising trend in ofloxacin resistance, re-emergence of erythromycin resistance and indications of co-resistance to both drugs in clinical isolates of Campylobacter spp.

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