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Kuroda A, Kaneto H, Kawashima S, et al. Regular insulin, rather than rapid-acting insulin, is a suitable choice for premeal bolus insulin in lean patients with type 2 diabetes mellitus. J Diabetes Investig. 2012;4(1):78-81doi: 10.1111/j.2040-1124.2012.00231.x.
Kuroda, A., Kaneto, H., Kawashima, S., Sakamoto, K., Takahara, M., Shiraiwa, T., Yasuda, T., Katakami, N., Matsuoka, T. A., Shimomura, I., & Matsuhisa, M. (2013). Regular insulin, rather than rapid-acting insulin, is a suitable choice for premeal bolus insulin in lean patients with type 2 diabetes mellitus. Journal of diabetes investigation, 4(1), 78-81. https://doi.org/10.1111/j.2040-1124.2012.00231.x
Kuroda, Akio, et al. "Regular insulin, rather than rapid-acting insulin, is a suitable choice for premeal bolus insulin in lean patients with type 2 diabetes mellitus." Journal of diabetes investigation vol. 4,1 (2013): 78-81. doi: https://doi.org/10.1111/j.2040-1124.2012.00231.x
Kuroda A, Kaneto H, Kawashima S, Sakamoto K, Takahara M, Shiraiwa T, Yasuda T, Katakami N, Matsuoka TA, Shimomura I, Matsuhisa M. Regular insulin, rather than rapid-acting insulin, is a suitable choice for premeal bolus insulin in lean patients with type 2 diabetes mellitus. J Diabetes Investig. 2013 Jan 29;4(1):78-81. doi: 10.1111/j.2040-1124.2012.00231.x. Epub 2012 Aug 21. PMID: 24843634; PMCID: PMC4019291.
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J Diabetes Investig. 2013 Jan 29;4(1):78-81. doi: 10.1111/j.2040-1124.2012.00231.x. Epub 2012 Aug 21.

Regular insulin, rather than rapid-acting insulin, is a suitable choice for premeal bolus insulin in lean patients with type 2 diabetes mellitus.

Journal of diabetes investigation

Akio Kuroda, Hideaki Kaneto, Satoshi Kawashima, Kenya Sakamoto, Mitsuyoshi Takahara, Toshihiko Shiraiwa, Tetsuyuki Yasuda, Naoto Katakami, Taka-Aki Matsuoka, Iichiro Shimomura, Munehide Matsuhisa

Affiliations

  1. Diabetes Therapeutics and Research Center The University of Tokushima Tokushima.
  2. Department of Metabolic Medicine Osaka University Graduate School of Medicine Osaka Japan.
  3. Department of Internal Medicine Osaka Police Hospital Osaka Japan.

PMID: 24843634 PMCID: PMC4019291 DOI: 10.1111/j.2040-1124.2012.00231.x

Abstract

The aim of the present study was to compare the usefulness of premeal rapid-acting and regular insulin in type 2 diabetes patients. A total of 56 type 2 diabetic patients were investigated during hospitalization. Premeal rapid-acting insulin was applied instead of other medications. Premeal insulin was titrated to adjust premeal and bedtime blood glucose levels to 81-120 mg/dL. Premeal rapid-acting insulin was changed to regular insulin just before a meal at the same dosage if the postmeal blood glucose level was lower than the premeal blood glucose level. A total of 15 patients changed to regular insulin, and 41 patients continued rapid-acting insulin. The blood glucose level was comparable between these two groups. Body mass index was significantly lower in the patients using regular insulin. According to the multivariate logistic regression analysis, low body mass index was an independent variable accounting for the usefulness of regular insulin. Regular insulin, rather than rapid-acting insulin, is a suitable choice for premeal insulin in lean type 2 diabetic patients.

Keywords: Hypoglycemia; Insulin action; Insulin therapy

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