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Imamura M, Iwata M, Maegawa H, et al. Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population. J Diabetes Investig. 2012;4(2):168-73doi: 10.1111/jdi.12017.
Imamura, M., Iwata, M., Maegawa, H., Watada, H., Hirose, H., Tanaka, Y., Tobe, K., Kaku, K., Kashiwagi, A., Kadowaki, T., Kawamori, R., & Maeda, S. (2013). Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population. Journal of diabetes investigation, 4(2), 168-73. https://doi.org/10.1111/jdi.12017
Imamura, Minako, et al. "Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population." Journal of diabetes investigation vol. 4,2 (2013): 168-73. doi: https://doi.org/10.1111/jdi.12017
Imamura M, Iwata M, Maegawa H, Watada H, Hirose H, Tanaka Y, Tobe K, Kaku K, Kashiwagi A, Kadowaki T, Kawamori R, Maeda S. Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population. J Diabetes Investig. 2013 Mar 18;4(2):168-73. doi: 10.1111/jdi.12017. Epub 2012 Nov 28. PMID: 24843648; PMCID: PMC4019271.
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J Diabetes Investig. 2013 Mar 18;4(2):168-73. doi: 10.1111/jdi.12017. Epub 2012 Nov 28.

Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population.

Journal of diabetes investigation

Minako Imamura, Minoru Iwata, Hiroshi Maegawa, Hirotaka Watada, Hiroshi Hirose, Yasushi Tanaka, Kazuyuki Tobe, Kohei Kaku, Atsunori Kashiwagi, Takashi Kadowaki, Ryuzo Kawamori, Shiro Maeda

Affiliations

  1. Laboratory for Endocrinology and Metabolism RIKEN Center for Genomic Medicine Yokohama Japan.
  2. First Department of Internal Medicine Toyama Japan ; Community Medical Support Unit, Faculty of Medicine University of Toyama Toyama Japan.
  3. Department of Medicine Shiga University of Medical Science Otsu Shiga Japan.
  4. Department of Medicine, Metabolism and Endocrinology School of Medicine Tokyo Japan ; Sportology Center Graduate School of Medicine, Juntendo University Tokyo Japan.
  5. Health Center Keio University School of Medicine Tokyo Japan.
  6. Division of Metabolism and Endocrinology, Department of Internal Medicine St. Marianna University School of Medicine Kawasaki Kanagawa Japan.
  7. First Department of Internal Medicine Toyama Japan.
  8. Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine Kawasaki Medical School Kurashiki Okayama Japan.
  9. Department of Diabetes and Metabolic Diseases Graduate School of Medicine, The University of Tokyo Tokyo Japan.
  10. Sportology Center Graduate School of Medicine, Juntendo University Tokyo Japan.

PMID: 24843648 PMCID: PMC4019271 DOI: 10.1111/jdi.12017

Abstract

AIMS/INTRODUCTION: Genetic risk variants for type 2 diabetes; rs391300-G in SRR and rs17584499-T in PTPRD, have been identified by a genome-wide association study using Han Chinese individuals living in Taiwan. In an attempt to know the effects of these two variants in conferring susceptibility to type 2 diabetes in the Japanese, we carried out a replication study for the association of the two single nucleotide polymorphisms (SNPs) with type 2 diabetes in a Japanese population.

MATERIALS AND METHODS: We genotyped 11,530 Japanese individuals (8,552 type 2 diabetes patients and 2,978 controls) for rs391300 and rs17584499, and analyzed the association of these two SNPs with type 2 diabetes by logistic regression analysis.

RESULTS: Neither of the variants was associated with susceptibility to type 2 diabetes in the Japanese population (rs391300-G: odds ratio [OR] = 0.97; 95% confidence interval [CI] 0.91-1.04; P = 0.44; rs17584499-T: OR = 1.04; 95% CI 0.96-1.14; P = 0.34). Adjustment or stratified analysis for age, sex and body mass index (BMI) did not affect the association of these variants with the disease. We did not observe a significant association of the SNPs with any metabolic traits, BMI, fasting plasma glucose, homeostasis model assessment of β-cell function (HOMA-β) and HOMA of insulin resistance (HOMA-IR) (P > 0.05).

CONCLUSIONS: Neither rs391300 nor rs17584499 had a significant effect on conferring susceptibility to type 2 diabetes in the Japanese population.

Keywords: Genetic association studies; Japanese; Type 2 diabetes mellitus

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