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Jülicher P, Dhein J. The Range of Uncertainty: a Tool for Efficiently Addressing Result Variability Around Clinical Decision Points for Hepatitis C Response-guided Therapy. Biomark Insights. 2014;9:9-13doi: 10.4137/BMI.S14481.
Jülicher, P., & Dhein, J. (2014). The Range of Uncertainty: a Tool for Efficiently Addressing Result Variability Around Clinical Decision Points for Hepatitis C Response-guided Therapy. Biomarker insights, 99-13. https://doi.org/10.4137/BMI.S14481
Jülicher, Paul, and Dhein, Jens. "The Range of Uncertainty: a Tool for Efficiently Addressing Result Variability Around Clinical Decision Points for Hepatitis C Response-guided Therapy." Biomarker insights vol. 9 (2014): 9-13. doi: https://doi.org/10.4137/BMI.S14481
Jülicher P, Dhein J. The Range of Uncertainty: a Tool for Efficiently Addressing Result Variability Around Clinical Decision Points for Hepatitis C Response-guided Therapy. Biomark Insights. 2014 Apr 09;9:9-13. doi: 10.4137/BMI.S14481. eCollection 2014. PMID: 24812481; PMCID: PMC3999813.
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Biomark Insights. 2014 Apr 09;9:9-13. doi: 10.4137/BMI.S14481. eCollection 2014.

The Range of Uncertainty: a Tool for Efficiently Addressing Result Variability Around Clinical Decision Points for Hepatitis C Response-guided Therapy.

Biomarker insights

Paul Jülicher, Jens Dhein

Affiliations

  1. Abbott GmbH and Co KG, Wiesbaden, Germany.

PMID: 24812481 PMCID: PMC3999813 DOI: 10.4137/BMI.S14481

Abstract

Despite efforts to standardize molecular diagnostic tests, performance differences are not rare. Laboratories are challenged in situations where treatment rules have been established using a reference assay that is different from the assays being used in daily practice. Assessing the viral load status of patients with chronic hepatitis C under modern triple therapy is a recognized example. We demonstrate the use of the range of uncertainty as an easy and efficient tool that can provide information on the certainty of a test result's interpretation in the context of making hepatitis C virus treatment decisions.

Keywords: hepatitis C; in vitro diagnostic tests; precision; response guided therapy; standardization; viral load

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