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Schmidt M, Hallas J, Friis S. Potential of prescription registries to capture individual-level use of aspirin and other nonsteroidal anti-inflammatory drugs in Denmark: trends in utilization 1999-2012. Clin Epidemiol. 2014;6:155-68doi: 10.2147/CLEP.S59156.
Schmidt, M., Hallas, J., & Friis, S. (2014). Potential of prescription registries to capture individual-level use of aspirin and other nonsteroidal anti-inflammatory drugs in Denmark: trends in utilization 1999-2012. Clinical epidemiology, 6155-68. https://doi.org/10.2147/CLEP.S59156
Schmidt, Morten, et al. "Potential of prescription registries to capture individual-level use of aspirin and other nonsteroidal anti-inflammatory drugs in Denmark: trends in utilization 1999-2012." Clinical epidemiology vol. 6 (2014): 155-68. doi: https://doi.org/10.2147/CLEP.S59156
Schmidt M, Hallas J, Friis S. Potential of prescription registries to capture individual-level use of aspirin and other nonsteroidal anti-inflammatory drugs in Denmark: trends in utilization 1999-2012. Clin Epidemiol. 2014 May 12;6:155-68. doi: 10.2147/CLEP.S59156. eCollection 2014. PMID: 24872722; PMCID: PMC4026552.
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Clin Epidemiol. 2014 May 12;6:155-68. doi: 10.2147/CLEP.S59156. eCollection 2014.

Potential of prescription registries to capture individual-level use of aspirin and other nonsteroidal anti-inflammatory drugs in Denmark: trends in utilization 1999-2012.

Clinical epidemiology

Morten Schmidt, Jesper Hallas, Søren Friis

Affiliations

  1. Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
  2. Department of Clinical Pharmacology, University of Southern Denmark, Odense, Denmark.
  3. Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark ; Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.

PMID: 24872722 PMCID: PMC4026552 DOI: 10.2147/CLEP.S59156

Abstract

BACKGROUND: Due to over-the-counter availability, no consensus exists on whether adequate information on nonsteroidal anti-inflammatory drug (NSAID) use can be obtained from prescription registries.

OBJECTIVES: To examine utilization of aspirin and nonaspirin NSAIDs in Denmark between 1999 and 2012 and to quantify the proportion of total sales that was sold on prescription.

METHOD: Based on nationwide data from the Danish Serum Institute and the Danish National Prescription Registry, we retrieved sales statistics for the Danish primary health care sector to calculate 1-year prevalences of prescription users of aspirin or nonaspirin NSAIDs, and to estimate the corresponding proportions of total sales dispensed on prescription.

RESULTS: Both low-dose aspirin and nonaspirin NSAIDs were commonly used in the Danish population between 1999 and 2012, particularly among elderly individuals. The 1-year prevalence of prescribed low-dose aspirin increased throughout the study period, notably among men. Nonaspirin NSAID use was frequent in all age groups above 15 years and showed a female preponderance. Overall, the prevalence of prescribed nonaspirin NSAIDs decreased moderately after 2004, but substantial variation according to NSAID subtype was observed; ibuprofen use increased, use of all newer selective cyclooxygenase-2 inhibitors nearly ceased after 2004, diclofenac use decreased by nearly 50% after 2008, and naproxen use remained stable. As of 2012, the prescribed proportion of individual-level NSAID sales was 92% for low-dose aspirin, 66% for ibuprofen, and 100% for all other NSAIDs.

CONCLUSION: The potential for identifying NSAID use from prescription registries in Denmark is high. Low-dose aspirin and nonaspirin NSAID use varied substantially between 1999 and 2012. Notably, use of cyclooxygenase-2 inhibitors nearly ceased, use of diclofenac decreased markedly, and naproxen use remained unaltered.

Keywords: NSAID; drug utilization; over-the-counter; registries

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