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Liang QQ, Ding DF, Xi ZJ, et al. Protective effect of ligustrazine on lumbar intervertebral disc degeneration of rats induced by prolonged upright posture. Evid Based Complement Alternat Med. 2014;2014:508461doi: 10.1155/2014/508461.
Liang, Q. Q., Ding, D. F., Xi, Z. J., Chen, Y., Li, C. G., Liu, S. F., Lu, S., Zhao, Y. J., Shi, Q., & Wang, Y. J. (2014). Protective effect of ligustrazine on lumbar intervertebral disc degeneration of rats induced by prolonged upright posture. Evidence-based complementary and alternative medicine : eCAM, 2014508461. https://doi.org/10.1155/2014/508461
Liang, Qian-Qian, et al. "Protective effect of ligustrazine on lumbar intervertebral disc degeneration of rats induced by prolonged upright posture." Evidence-based complementary and alternative medicine : eCAM vol. 2014 (2014): 508461. doi: https://doi.org/10.1155/2014/508461
Liang QQ, Ding DF, Xi ZJ, Chen Y, Li CG, Liu SF, Lu S, Zhao YJ, Shi Q, Wang YJ. Protective effect of ligustrazine on lumbar intervertebral disc degeneration of rats induced by prolonged upright posture. Evid Based Complement Alternat Med. 2014;2014:508461. doi: 10.1155/2014/508461. Epub 2014 Apr 29. PMID: 24872832; PMCID: PMC4020374.
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Evid Based Complement Alternat Med. 2014;2014:508461. doi: 10.1155/2014/508461. Epub 2014 Apr 29.

Protective effect of ligustrazine on lumbar intervertebral disc degeneration of rats induced by prolonged upright posture.

Evidence-based complementary and alternative medicine : eCAM

Qian-Qian Liang, Dao-Fang Ding, Zhi-Jie Xi, Yan Chen, Chen-Guang Li, Shu-Fen Liu, Sheng Lu, Yong-Jian Zhao, Qi Shi, Yong-Jun Wang

Affiliations

  1. Institute of Spine, Shanghai University of Traditional Chinese Medicine, 725 Wan-Ping South Road, Shanghai 200032, China ; Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

PMID: 24872832 PMCID: PMC4020374 DOI: 10.1155/2014/508461

Abstract

Most chronic low back pain is the result of degeneration of the lumbar intervertebral disc. Ligustrazine, an alkaloid from Chuanxiong, reportedly is able to relieve pain, suppress inflammation, and treat osteoarthritis and it has the protective effect on cartilage and chondrocytes. Therefore, we asked whether ligustrazine could reduce intervertebral disc degeneration. To determine the effect of ligustrazine on disc degeneration, we applied a rat model. The intervertebral disc degeneration of the rats was induced by prolonged upright posture. We found that pretreatment with ligustrazine for 1 month recovered the structural distortion of the degenerative disc; inhibited the expression of type X collagen, matrix metalloproteinase (MMP)-13, and MMP3; upregulated type II collagen; and decreased IL-1 β , cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) expression. In conclusion, ligustrazine is a promising agent for treating lumbar intervertebral disc degeneration disease.

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