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Raffeiner B, Ometto F, Bernardi L, et al. Inefficacy or paradoxical effect? Uveitis in ankylosing spondylitis treated with etanercept. Case Rep Med. 2014;2014:471319doi: 10.1155/2014/471319.
Raffeiner, B., Ometto, F., Bernardi, L., Botsios, C., & Punzi, L. (2014). Inefficacy or paradoxical effect? Uveitis in ankylosing spondylitis treated with etanercept. Case reports in medicine, 2014471319. https://doi.org/10.1155/2014/471319
Raffeiner, Bernd, et al. "Inefficacy or paradoxical effect? Uveitis in ankylosing spondylitis treated with etanercept." Case reports in medicine vol. 2014 (2014): 471319. doi: https://doi.org/10.1155/2014/471319
Raffeiner B, Ometto F, Bernardi L, Botsios C, Punzi L. Inefficacy or paradoxical effect? Uveitis in ankylosing spondylitis treated with etanercept. Case Rep Med. 2014;2014:471319. doi: 10.1155/2014/471319. Epub 2014 Jun 04. PMID: 24991219; PMCID: PMC4065678.
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Case Rep Med. 2014;2014:471319. doi: 10.1155/2014/471319. Epub 2014 Jun 04.

Inefficacy or paradoxical effect? Uveitis in ankylosing spondylitis treated with etanercept.

Case reports in medicine

Bernd Raffeiner, Francesca Ometto, Livio Bernardi, Costantino Botsios, Leonardo Punzi

Affiliations

  1. Rheumatology Unit, Department of Medicine, General Hospital of Bolzano, Lorenz Boehler Street No. 5, 39100 Bolzano, Italy.
  2. Rheumatology Unit, Department of Medicine, University of Padova, 35128 Padova, Italy.

PMID: 24991219 PMCID: PMC4065678 DOI: 10.1155/2014/471319

Abstract

Ankylosing spondylitis (AS) is presented with axial and peripheral articular involvement. Uveitis is a severe and rather specific manifestation of AS. Biologics targeting tumor necrosis factor (TNF) α are effective on both articular and ocular manifestations of disease. The occurrence of uveitis in patients that never had eye involvement or the relapse of uveitis is described during anti-TNF α treatment. The frequency of these events is slightly higher during therapy with etanercept. The available TNF α blockers show different pharmacokinetics and pharmacodynamics yielding different biological effects. There is an ongoing debate whether uveitis during anti-TNF α has to be considered as paradoxical effect or an inadequate response to therapy. Here, we present a case report and review what the evidences for the two hypotheses are.

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