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Aboutaleb HA, Elsherif EA, Omar MK, et al. Testicular Biopsy Histopathology as an Indicator of Successful Restoration of Spermatogenesis after Varicocelectomy in Non-obstructive Azoospermia. World J Mens Health. 2014;32(1):43-9doi: 10.5534/wjmh.2014.32.1.43.
Aboutaleb, H. A., Elsherif, E. A., Omar, M. K., & Abdelbaky, T. M. (2014). Testicular Biopsy Histopathology as an Indicator of Successful Restoration of Spermatogenesis after Varicocelectomy in Non-obstructive Azoospermia. The world journal of men's health, 32(1), 43-9. https://doi.org/10.5534/wjmh.2014.32.1.43
Aboutaleb, Hamdy Abdelmawla, et al. "Testicular Biopsy Histopathology as an Indicator of Successful Restoration of Spermatogenesis after Varicocelectomy in Non-obstructive Azoospermia." The world journal of men's health vol. 32,1 (2014): 43-9. doi: https://doi.org/10.5534/wjmh.2014.32.1.43
Aboutaleb HA, Elsherif EA, Omar MK, Abdelbaky TM. Testicular Biopsy Histopathology as an Indicator of Successful Restoration of Spermatogenesis after Varicocelectomy in Non-obstructive Azoospermia. World J Mens Health. 2014 Apr;32(1):43-9. doi: 10.5534/wjmh.2014.32.1.43. Epub 2014 Apr 25. PMID: 24872951; PMCID: PMC4026233.
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World J Mens Health. 2014 Apr;32(1):43-9. doi: 10.5534/wjmh.2014.32.1.43. Epub 2014 Apr 25.

Testicular Biopsy Histopathology as an Indicator of Successful Restoration of Spermatogenesis after Varicocelectomy in Non-obstructive Azoospermia.

The world journal of men's health

Hamdy Abdelmawla Aboutaleb, Eid Abdel-Rasoul Elsherif, Mohammed Kamal Omar, Tarek Mohammed Abdelbaky

Affiliations

  1. Department of Urology, Minoufiya University Hospitals, Minoufiya, Egypt.

PMID: 24872951 PMCID: PMC4026233 DOI: 10.5534/wjmh.2014.32.1.43

Abstract

PURPOSE: We aimed to evaluate the efficacy of using testicular biopsy histopathology as an indicator of the success of loupe-assisted subinguinal varicocelectomy in non-obstructive azoospermia (NOA) patients.

MATERIALS AND METHODS: In a 2-year period, a prospective study was carried at Minoufiya University Hospital on 20 NOA patients with clinical bilateral varicoceles. These patients underwent loupe-assisted subinguinal varicocelectomy with simultaneous testicular biopsy. All patients were evaluated by determining their hormonal profile and performing semen analyses and scrotal Doppler and transrectal ultrasonography. Two semen analyses showing azoospermia were performed before the surgery and two semen analyses were received at 3 and 6 months post-operatively for follow-up.

RESULTS: The mean age was 29.9±6.7 years, and the mean follow-up duration was 17.3±8.3 months. We noted the restoration of spermatogenesis in six men (30% of all patients). Testicular biopsy results were as follows: hypospermatogenesis in 7 patients, maturation arrest in 3, and Sertoli cell-only syndrome in 10. The improvement in the sperm counts of these patients ranged from 3 million to 15 million/mL. Sperms were recovered in the hypospermatogenesis (6 patients, 85.5%) patients only, but other patients with testicular biopsy results of Sertoli cell-only or maturation arrest did not show any improvement in their semen parameters.

CONCLUSIONS: Testicular biopsy results showed that hypospermatogenesis patients have a better chance of improvement in their semen analysis after varicocelectomy in contrast to NOA patients with Sertoli cell-only syndrome or maturation arrest.

Keywords: Azoospermia; Histology; Testis; Varicocele

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