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Kim YH, Ida M, Yamashita S, et al. Anti-Allergic Effects of Kakrol (Momordica dioica Roxb.) Flesh Extract. Biosci Microbiota Food Health. 2012;31(1):1-6doi: 10.12938/bmfh.31.1.
Kim, Y. H., Ida, M., Yamashita, S., Tsukamoto, S., Kumazoe, M., Sumida, M., Kawakami, M., Yamada, K., & Tachibana, H. (2012). Anti-Allergic Effects of Kakrol (Momordica dioica Roxb.) Flesh Extract. Bioscience of microbiota, food and health, 31(1), 1-6. https://doi.org/10.12938/bmfh.31.1
Kim, Yoon Hee, et al. "Anti-Allergic Effects of Kakrol (Momordica dioica Roxb.) Flesh Extract." Bioscience of microbiota, food and health vol. 31,1 (2012): 1-6. doi: https://doi.org/10.12938/bmfh.31.1
Kim YH, Ida M, Yamashita S, Tsukamoto S, Kumazoe M, Sumida M, Kawakami M, Yamada K, Tachibana H. Anti-Allergic Effects of Kakrol (Momordica dioica Roxb.) Flesh Extract. Biosci Microbiota Food Health. 2012;31(1):1-6. doi: 10.12938/bmfh.31.1. Epub 2012 Jan 31. PMID: 24936343; PMCID: PMC4034278.
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Biosci Microbiota Food Health. 2012;31(1):1-6. doi: 10.12938/bmfh.31.1. Epub 2012 Jan 31.

Anti-Allergic Effects of Kakrol (Momordica dioica Roxb.) Flesh Extract.

Bioscience of microbiota, food and health

Yoon Hee Kim, Megumi Ida, Shuya Yamashita, Shuntaro Tsukamoto, Motofumi Kumazoe, Mami Sumida, Mitsuo Kawakami, Koji Yamada, Hirofumi Tachibana

Affiliations

  1. Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
  2. Branch of Ishigaki, Okinawa Prefectural Agricultural Research Center, 1178-6 Hirae-Chisokobaru, Ishigaki, Okinawa 907-0003, Japan.

PMID: 24936343 PMCID: PMC4034278 DOI: 10.12938/bmfh.31.1

Abstract

We examined the inhibitory effect of the extract of kakrol extracted by 3 types of solvent (water, 50% and 100% ethanol) on histamine release in human basophilic KU812 cells. The water extract of kakrol flesh showed the strongest inhibitory effect on histamine release as compared with the other extracts. Therefore, we evaluated whether water extract of kakrol flesh had a suppressive effect on development of atopic dermatitis-like lesions in picryl chloride-treated NC/Nga mice. The dietary kakrol flesh water extract alleviated the development of skin lesions in ears accompanied by lower IgE levels and inflammatory cytokines levels in serum. These results indicate that the water extract of kakrol flesh might have therapeutic potential for allergic responses in vitro and in vivo.

Keywords: Kakrol; Momordica dioica Roxb.; atopic dermatitis; histamine

References

  1. Allergy. 1989;44 Suppl 9:16-9 - PubMed
  2. J Clin Invest. 2004 Mar;113(5):651-7 - PubMed
  3. Immunol Rev. 2011 Jul;242(1):128-43 - PubMed
  4. J Invest Dermatol. 1994 Jan;102(1):128-37 - PubMed
  5. Int Immunopharmacol. 2003 Sep;3(9):1313-24 - PubMed
  6. Exp Biol Med (Maywood). 2011 Oct;236(10):1139-46 - PubMed
  7. Int Immunol. 1997 Mar;9(3):461-6 - PubMed
  8. J Agric Food Chem. 2006 Jul 12;54(14):5203-7 - PubMed
  9. Int Arch Allergy Immunol. 1999;120 Suppl 1:70-5 - PubMed
  10. Immunol Today. 1998 Aug;19(8):359-61 - PubMed
  11. J Immunol. 1997 Sep 1;159(5):2484-91 - PubMed
  12. Clin Rev Allergy Immunol. 2011 Dec;41(3):298-310 - PubMed
  13. Nat Prod Res. 2010 Sep;24(15):1379-89 - PubMed
  14. J Exp Med. 2000 Nov 20;192(10):1441-52 - PubMed
  15. J Allergy Clin Immunol. 2000 Jul;106(1 Pt 1):110-6 - PubMed
  16. Int Arch Allergy Immunol. 2004 Apr;133(4):389-97 - PubMed
  17. Allergy. 1989;44 Suppl 9:31-4 - PubMed
  18. J Dermatol Sci. 2004 Oct;36(1):1-9 - PubMed
  19. J Allergy Clin Immunol. 2003 Dec;112(6 Suppl):S128-39 - PubMed
  20. Ann Allergy Asthma Immunol. 2000 Jun;84(6):569-79; quiz 579-81 - PubMed
  21. J Invest Dermatol. 1995 Dec;105(6):749-55 - PubMed
  22. Nat Prod Res. 2010 May;24(9):846-54 - PubMed

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