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Yanai J, Fishman RH. Resistance to barbiturate is changed by developmental alteration of dopamine receptor sensitivity. Int J Dev Neurosci. 1984;2(1):61-4doi: 10.1016/0736-5748(84)90060-1.
Yanai, J., & Fishman, R. H. (1984). Resistance to barbiturate is changed by developmental alteration of dopamine receptor sensitivity. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2(1), 61-4. https://doi.org/10.1016/0736-5748(84)90060-1
Yanai, J, and Fishman, R H. "Resistance to barbiturate is changed by developmental alteration of dopamine receptor sensitivity." International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience vol. 2,1 (1984): 61-4. doi: https://doi.org/10.1016/0736-5748(84)90060-1
Yanai J, Fishman RH. Resistance to barbiturate is changed by developmental alteration of dopamine receptor sensitivity. Int J Dev Neurosci. 1984;2(1):61-4. doi: 10.1016/0736-5748(84)90060-1. PMID: 24873853.
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Int J Dev Neurosci. 1984;2(1):61-4. doi: 10.1016/0736-5748(84)90060-1.

Resistance to barbiturate is changed by developmental alteration of dopamine receptor sensitivity.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

J Yanai, R H Fishman

Affiliations

  1. Department of Anatomy and Embryology, Hebrew University-Hadassah Medical School, P.O. Box 1172, 91010 Jerusalem, Israel.

PMID: 24873853 DOI: 10.1016/0736-5748(84)90060-1

Abstract

Adult rats whose dopamine receptor number was reduced via prenatal haloperidol exposure were less resistant than controls to pentobarbital narcosis. This altered resistance was functional (CNS) and not metabolic, as shown by pentobarbital brain levels. These results are consistent with our previous experiments, indicating that changes in the number of dopamine receptors may underlie relative susceptibility to barbiturates.

Copyright © 1984. Published by Elsevier Ltd.

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