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Berger JJ, Bates GW. Optimal management of subfertility in polycystic ovary syndrome. Int J Womens Health. 2014;6:613-21doi: 10.2147/IJWH.S48527.
Berger, J. J., & Bates, G. W. (2014). Optimal management of subfertility in polycystic ovary syndrome. International journal of women's health, 6613-21. https://doi.org/10.2147/IJWH.S48527
Berger, Joshua J, and Bates, G Wright. "Optimal management of subfertility in polycystic ovary syndrome." International journal of women's health vol. 6 (2014): 613-21. doi: https://doi.org/10.2147/IJWH.S48527
Berger JJ, Bates GW. Optimal management of subfertility in polycystic ovary syndrome. Int J Womens Health. 2014 Jun 13;6:613-21. doi: 10.2147/IJWH.S48527. eCollection 2014. PMID: 24966697; PMCID: PMC4063802.
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Int J Womens Health. 2014 Jun 13;6:613-21. doi: 10.2147/IJWH.S48527. eCollection 2014.

Optimal management of subfertility in polycystic ovary syndrome.

International journal of women's health

Joshua J Berger, G Wright Bates

Affiliations

  1. University of Alabama at Birmingham, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Birmingham, AL, USA.

PMID: 24966697 PMCID: PMC4063802 DOI: 10.2147/IJWH.S48527

Abstract

The purpose of this paper is to provide a stepwise approach to treating the infertility/subfertility associated with polycystic ovary syndrome. Defining polycystic ovary syndrome in a patient requires first investigating other possible causes for polycystic ovary morphology, acne, hirsutism, obesity, and the metabolic derangements that often accompany polycystic ovary syndrome. Beginning with lifestyle modification and use of metformin, the progressive inclusion of more intensive therapies for induction of ovulation is described. Second-line treatments are discussed and the new findings from a large multicenter trial are discussed in the context of evidence-based treatment strategies for first-line agents. Finally, monofollicular development as a treatment goal and in vitro fertilization are discussed for those with recalcitrant disease.

Keywords: infertility; metformin; ovarian drilling; ovulation induction; polycystic ovary syndrome; subfertility

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