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Romano MC, Velázquez PN, Nún̄ez MB, et al. Effect of glucocorticoids on development of the membrane resting potential of chick embryo brain cells in culture. Int J Dev Neurosci. 1985;3(5):521-9doi: 10.1016/0736-5748(85)90041-3.
Romano, M. C., Velázquez, P. N., Nún̄ez, M. B., & Fuentes-Pardo, B. (1985). Effect of glucocorticoids on development of the membrane resting potential of chick embryo brain cells in culture. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 3(5), 521-9. https://doi.org/10.1016/0736-5748(85)90041-3
Romano, M C, et al. "Effect of glucocorticoids on development of the membrane resting potential of chick embryo brain cells in culture." International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience vol. 3,5 (1985): 521-9. doi: https://doi.org/10.1016/0736-5748(85)90041-3
Romano MC, Velázquez PN, Nún̄ez MB, Fuentes-Pardo B. Effect of glucocorticoids on development of the membrane resting potential of chick embryo brain cells in culture. Int J Dev Neurosci. 1985;3(5):521-9. doi: 10.1016/0736-5748(85)90041-3. PMID: 24874961.
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Int J Dev Neurosci. 1985;3(5):521-9. doi: 10.1016/0736-5748(85)90041-3.

Effect of glucocorticoids on development of the membrane resting potential of chick embryo brain cells in culture.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

M C Romano, P N Velázquez, M B Nún̄ez, B Fuentes-Pardo

Affiliations

  1. Departamento de Fisiología, C.I.E.A. del I.P.N. Apdo, Postal 14-740, México, D.F. 07000, México.
  2. Departamentos de Histología y Fisiología, División de Investigatión, Facultad de Medicina, U.K.A.M. Apdo, Postal 70-250, México, D.F. 04510, México.

PMID: 24874961 DOI: 10.1016/0736-5748(85)90041-3

Abstract

Progressive increase in membrane resting potential (MRP) values in cultured chick embryo brain neurons were recorded from days 2 to 10 of development. Application of corticosterone or prednisone in 24 hr old cultured cells caused a significant increment in MRP recorded at day 2 of culture with respect to control. When ouabain was added to the corticosterone treated cells its effect on the MRP was impaired. An increment in protein synthesis and a reduction in sodium concentration were also observed in corticosterone pretreated cells. These results show that corticoids accelerate the differentiation process in cultured cells particularly the MRP, stimulating perhaps the Na(+)-K(+) ATPase pump.

Copyright © 1985. Published by Elsevier Ltd.

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