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You H, Stephenson RJ, Gobert GN, et al. Revisiting glucose uptake and metabolism in schistosomes: new molecular insights for improved schistosomiasis therapies. Front Genet. 2014;5:176doi: 10.3389/fgene.2014.00176.
You, H., Stephenson, R. J., Gobert, G. N., & McManus, D. P. (2014). Revisiting glucose uptake and metabolism in schistosomes: new molecular insights for improved schistosomiasis therapies. Frontiers in genetics, 5176. https://doi.org/10.3389/fgene.2014.00176
You, Hong, et al. "Revisiting glucose uptake and metabolism in schistosomes: new molecular insights for improved schistosomiasis therapies." Frontiers in genetics vol. 5 (2014): 176. doi: https://doi.org/10.3389/fgene.2014.00176
You H, Stephenson RJ, Gobert GN, McManus DP. Revisiting glucose uptake and metabolism in schistosomes: new molecular insights for improved schistosomiasis therapies. Front Genet. 2014 Jun 11;5:176. doi: 10.3389/fgene.2014.00176. eCollection 2014. PMID: 24966871; PMCID: PMC4052099.
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Front Genet. 2014 Jun 11;5:176. doi: 10.3389/fgene.2014.00176. eCollection 2014.

Revisiting glucose uptake and metabolism in schistosomes: new molecular insights for improved schistosomiasis therapies.

Frontiers in genetics

Hong You, Rachel J Stephenson, Geoffrey N Gobert, Donald P McManus

Affiliations

  1. Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute Brisbane, QLD, Australia.
  2. Faculty of Science, School of Chemistry and Molecular Biosciences, The University of Queensland Brisbane, QLD, Australia.

PMID: 24966871 PMCID: PMC4052099 DOI: 10.3389/fgene.2014.00176

Abstract

A better understanding of the molecular mechanisms required for schistosomes to take up glucose, the major nutritional source exploited by these blood flukes from their mammalian hosts and the subsequent metabolism required to fuel growth and fecundity, can provide new avenues for developing novel interventions for the control of schistosomiasis. This aspect of parasitism is particularly important to paired adult schistosomes, due to their considerable requirements for the energy needed to produce the extensive numbers of eggs laid daily by the female worm. This review describes recent advances in characterizing glucose metabolism in adult schistosomes. Potential intervention targets are discussed within the insulin signaling and glycolysis pathways, both of which play critical roles in the carbohydrate and energy requirements of schistosomes.

Keywords: Schistosoma; glucose uptake and metabolism; glycolysis signaling pathway; insulin signaling pathway; schistosome

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