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Guclu O, Caliskan A, Karahan O, et al. Values of troponin T and myoglobin predictive of non-cardiac ischemia in rats. Iran J Basic Med Sci. 2014;17(5):318-21
Guclu, O., Caliskan, A., Karahan, O., Demirtas, S., Yazici, S., Yavuz, C., & Mavitas, B. (2014). Values of troponin T and myoglobin predictive of non-cardiac ischemia in rats. Iranian journal of basic medical sciences, 17(5), 318-21.
Guclu, Orkut, et al. "Values of troponin T and myoglobin predictive of non-cardiac ischemia in rats." Iranian journal of basic medical sciences vol. 17,5 (2014): 318-21.
Guclu O, Caliskan A, Karahan O, Demirtas S, Yazici S, Yavuz C, Mavitas B. Values of troponin T and myoglobin predictive of non-cardiac ischemia in rats. Iran J Basic Med Sci. 2014 May;17(5):318-21. PMID: 24967059; PMCID: PMC4069840.
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Iran J Basic Med Sci. 2014 May;17(5):318-21.

Values of troponin T and myoglobin predictive of non-cardiac ischemia in rats.

Iranian journal of basic medical sciences

Orkut Guclu, Ahmet Caliskan, Oguz Karahan, Sinan Demirtas, Suleyman Yazici, Celal Yavuz, Binali Mavitas

Affiliations

  1. Medical School of Dicle University, Department of Cardiovascular Surgery, Diyarbakir, Turkey.

PMID: 24967059 PMCID: PMC4069840

Abstract

OBJECTIVES: Biochemical markers are important for the timely diagnosis and follow-up of ischemic events. Most of the markers have been previously studied in the context of cardiac ischemia. However, research on markers of non-cardiac events has been insufficient. Therefore, we investigated the relationship between troponin and myoglobin which are commonly used markers of cardiac ischemia, in non-cardiac ischemia.

MATERIALS AND METHODS: Forty-eight rats were equally divided into six groups. Group I was the control group. Group II was the sham group and received a simple laparotomy. The superior mesenteric artery was clamped in groups III and IV in order to create mesenteric ischemia. The left femoral artery was clamped in groups V and VI in order to create peripheral ischemia. Intracardiac blood samples were taken from all groups (during the 3(rd) hour of ischemia in groups III and V and the 6(th) hour of ischemia in group IV and VI) and troponin T and myoglobin levels were measured.

RESULTS: Troponin and myoglobin levels were statistically similar in groups I and II. Moreover, increments were detected for troponin and myoglobin in ischemia groups according to group I and II. Furthermore, higher troponin Tlevels were detected after three hours of mesenteric ischemia and higher myoglobin values were observed after six hours of mesenteric ischemia (P<0.05).

CONCLUSION: Troponin T and myoglobin are not specific for non-cardiac ischemia, and they may be useful for detecting other ischemic events.

Keywords: Mesenteric ischemia; Myoglobin; Peripheral ischemia; Troponin T

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