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Cappuccini B, Torlone E, Ferri C, et al. Renal echo-3D and microalbuminuria in children of diabetic mothers: a preliminary study. J Dev Orig Health Dis. 2013;4(4):285-9doi: 10.1017/S204017441300007X.
Cappuccini, B., Torlone, E., Ferri, C., Arnone, S., Troiani, S., Bini, V., Bellomo, G., Barboni, G., & Di Renzo, G. (2013). Renal echo-3D and microalbuminuria in children of diabetic mothers: a preliminary study. Journal of developmental origins of health and disease, 4(4), 285-9. https://doi.org/10.1017/S204017441300007X
Cappuccini, B, et al. "Renal echo-3D and microalbuminuria in children of diabetic mothers: a preliminary study." Journal of developmental origins of health and disease vol. 4,4 (2013): 285-9. doi: https://doi.org/10.1017/S204017441300007X
Cappuccini B, Torlone E, Ferri C, Arnone S, Troiani S, Bini V, Bellomo G, Barboni G, Di Renzo G. Renal echo-3D and microalbuminuria in children of diabetic mothers: a preliminary study. J Dev Orig Health Dis. 2013 Aug;4(4):285-9. doi: 10.1017/S204017441300007X. PMID: 24993001.
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J Dev Orig Health Dis. 2013 Aug;4(4):285-9. doi: 10.1017/S204017441300007X.

Renal echo-3D and microalbuminuria in children of diabetic mothers: a preliminary study.

Journal of developmental origins of health and disease

B Cappuccini, E Torlone, C Ferri, S Arnone, S Troiani, V Bini, G Bellomo, G Barboni, G Di Renzo

Affiliations

  1. 1 Department of Neonatology, University Hospital of Perugia, Perugia, Italy.
  2. 2 MISEM, University Hospital of Perugia, Perugia, Italy.
  3. 3 Clinical Pathology, University Hospital of Perugia, Perugia, Italy.
  4. 4 Pediatric Cardiology, University Hospital of Perugia, Perugia, Italy.
  5. 5 Department of Nephrology, MVT Hospital, Todi (PG), Italy.
  6. 6 Department of Obstetrics/Gynecology and Centre of Perinatal, Santa Maria della Misericordia Hospital, University Hospital of Perugia, Perugia, Italy.

PMID: 24993001 DOI: 10.1017/S204017441300007X

Abstract

Maternal diabetes has assumed epidemic relevance in recent years and animal studies have provided some evidence that it may cause abnormalities in renal development and a reduction in nephron endowment in the offspring; however, human data are lacking. The renal cortex contains ∼95% of the glomeruli and its volume could be taken as a surrogate measure of glomerular number; based on this assumption, we measured renal cortex volume and in addition, microalbuminuria in a homogeneous sample of 42 children of diabetic (pregestational, n = 13, and gestational, n = 29) mothers, compared with 21 healthy children born of non-diabetic mothers. The offspring of diabetic mothers showed a significant reduction of renal cortex volume and higher albumin excretion compared with controls, possibly attributable to a reduction in the number of nephrons and the difference was statistically significant (P < 0.001). Although further studies on a larger sample are necessary, our preliminary findings suggest that maternal diabetes may affect renal development with sequelae later in life, requiring closer monitoring and follow-up. Furthermore, the importance of strict maternal diabetes management and control must be emphasized.

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