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Kaszuba E, Wagner B, Odeberg H, et al. Using NT-proBNP to Detect Chronic Heart Failure in Elderly Patients with Chronic Obstructive Pulmonary Disease. ISRN Family Med. 2013;2013:273864doi: 10.5402/2013/273864.
Kaszuba, E., Wagner, B., Odeberg, H., & Halling, A. (2013). Using NT-proBNP to Detect Chronic Heart Failure in Elderly Patients with Chronic Obstructive Pulmonary Disease. ISRN family medicine, 2013273864. https://doi.org/10.5402/2013/273864
Kaszuba, Elzbieta, et al. "Using NT-proBNP to Detect Chronic Heart Failure in Elderly Patients with Chronic Obstructive Pulmonary Disease." ISRN family medicine vol. 2013 (2013): 273864. doi: https://doi.org/10.5402/2013/273864
Kaszuba E, Wagner B, Odeberg H, Halling A. Using NT-proBNP to Detect Chronic Heart Failure in Elderly Patients with Chronic Obstructive Pulmonary Disease. ISRN Family Med. 2013 Jun 09;2013:273864. doi: 10.5402/2013/273864. eCollection 2013. PMID: 24967321; PMCID: PMC4041248.
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ISRN Family Med. 2013 Jun 09;2013:273864. doi: 10.5402/2013/273864. eCollection 2013.

Using NT-proBNP to Detect Chronic Heart Failure in Elderly Patients with Chronic Obstructive Pulmonary Disease.

ISRN family medicine

Elzbieta Kaszuba, Bartlomiej Wagner, Håkan Odeberg, Anders Halling

Affiliations

  1. Blekinge Competence Centre, Wämö Centre, 371 81 Karlskrona, Sweden ; Lund University, Department of Clinical Sciences in Malmö, General Practice/Family Medicine, 205 02 Malmö, Sweden.
  2. Blekinge Competence Centre, Wämö Centre, 371 81 Karlskrona, Sweden.
  3. Blekinge Competence Centre, Wämö Centre, 371 81 Karlskrona, Sweden ; Lund University, Department of Clinical Sciences in Malmö, General Practice/Family Medicine, 205 02 Malmö, Sweden ; Research Unit of General Practice, Institute of Public Health, University of Southern Denmark, 5000 Odense C, Denmark.

PMID: 24967321 PMCID: PMC4041248 DOI: 10.5402/2013/273864

Abstract

Objective. To detect chronic heart failure in elderly patients with a registered diagnosis of chronic obstructive pulmonary disease (COPD) treated in Swedish primary health care using natriuretic peptide NT-proBNP. Design. A cross-sectional study. Setting. Two primary health care centres in southeastern Sweden each with about 9000 listed patients. Subjects. Patients aged 65 years and older with a registered diagnosis of COPD. Main Outcome Measures. Percentage of patients with elevated NT-proBNP, percentage of patients with abnormal left ventricular function assessed by echocardiography, and association between elevated NT-proBNP and symptoms, signs, and electrocardiography. Results. Using NT-proBNP threshold of 1200 pg/mL, we could detect and confirm chronic heart failure in 5.6% of the study population with concurrent COPD. An elevated level of NT-proBNP was only associated with nocturia and abnormal electrocardiography. Conclusions. We found considerably fewer cases of heart failure in patients with COPD than could be expected from the results of previous studies. Our study shows the need for developing improved strategies to enhance the validity of a suspected heart failure diagnosis in patients with COPD.

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