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Ariyanon W, Mao H, Adýbelli Z, et al. Renal denervation: intractable hypertension and beyond. Cardiorenal Med. 2014;4(1):22-33doi: 10.1159/000357597.
Ariyanon, W., Mao, H., Adýbelli, Z., Romano, S., Rodighiero, M., Reimers, B., La Vecchia, L., & Ronco, C. (2014). Renal denervation: intractable hypertension and beyond. Cardiorenal medicine, 4(1), 22-33. https://doi.org/10.1159/000357597
Ariyanon, Wassawon, et al. "Renal denervation: intractable hypertension and beyond." Cardiorenal medicine vol. 4,1 (2014): 22-33. doi: https://doi.org/10.1159/000357597
Ariyanon W, Mao H, Adýbelli Z, Romano S, Rodighiero M, Reimers B, La Vecchia L, Ronco C. Renal denervation: intractable hypertension and beyond. Cardiorenal Med. 2014 Apr;4(1):22-33. doi: 10.1159/000357597. Epub 2014 Jan 15. PMID: 24847331; PMCID: PMC4024497.
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Cardiorenal Med. 2014 Apr;4(1):22-33. doi: 10.1159/000357597. Epub 2014 Jan 15.

Renal denervation: intractable hypertension and beyond.

Cardiorenal medicine

Wassawon Ariyanon, Huijuan Mao, Zelal Adýbelli, Silvia Romano, Mariapia Rodighiero, Bernhard Reimers, Luigi La Vecchia, Claudio Ronco

Affiliations

  1. Department of Nephrology, San Bortolo Hospital, Italy ; International Renal Research Institute Vicenza (IRRIV), Italy ; Cardio-Metabolic Center, BNH Hospital, Bangkok, Thailand.
  2. Department of Nephrology, San Bortolo Hospital, Italy ; International Renal Research Institute Vicenza (IRRIV), Italy ; Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  3. Department of Nephrology, San Bortolo Hospital, Italy ; International Renal Research Institute Vicenza (IRRIV), Italy.
  4. Department of Cardiology, City Hospital, Milan, Italy.
  5. Department of Cardiology, San Bortolo Hospital, Vicenza, Italy.

PMID: 24847331 PMCID: PMC4024497 DOI: 10.1159/000357597

Abstract

BACKGROUND: Hypertension continues to be a major burden of public health concern despite the recent advances and proven benefit of pharmacological therapy. A certain subset of patients has hypertension resistant to maximal medical therapy and appropriate lifestyle measures. A novel catheter-based technique for renal denervation (RDN) as a new therapeutic avenue has great promise for the treatment of refractory hypertension.

SUMMARY: This review included the physiology of the renal sympathetic nervous system and the renal nerve anatomy. Furthermore, the RDN procedure, technology systems, and RDN clinical trials as well as findings besides antihypertensive effects were discussed. Findings on safety and efficacy seem to suggest that renal sympathetic denervation could be of therapeutic benefit in refractory hypertensive patients. Despite the fast pace of development in RDN therapies, only initial and very limited clinical data are available. Large gaps in knowledge concerning the long-term effects and consequences of RDN still exist, and solid, randomized data are warranted.

Keywords: Hypertension; Renal denervation; Renal sympathetic nervous system

References

  1. Circulation. 2011 May 10;123(18):1940-6 - PubMed
  2. Hypertension. 2011 Oct;58(4):559-65 - PubMed
  3. Circulation. 2008 Jun 24;117(25):e510-26 - PubMed
  4. Hypertension. 2004 Feb;43(2):169-75 - PubMed
  5. Swiss Med Wkly. 2012 Jul 17;142:w13638 - PubMed
  6. Eur Heart J. 2013 Jul;34(28):2149-57 - PubMed
  7. Hypertension. 2008 Jun;51(6):1403-19 - PubMed
  8. J Vasc Interv Radiol. 2013 May;24(5):632-9 - PubMed
  9. N Engl J Med. 1992 Dec 31;327(27):1912-8 - PubMed
  10. EuroIntervention. 2013 Jan 22;8(9):1090-4 - PubMed
  11. JACC Cardiovasc Interv. 2012 Mar;5(3):249-58 - PubMed
  12. Eur Heart J. 2013 Jul;34(28):2141-8, 2148b - PubMed
  13. Cardiovasc Diabetol. 2011 Apr 17;10:33 - PubMed
  14. Lancet. 2012 Aug 25;380(9843):778 - PubMed
  15. J Am Coll Cardiol. 2012 Mar 6;59(10):901-9 - PubMed
  16. Clin Cardiol. 2012 Sep;35(9):528-35 - PubMed
  17. N Engl J Med. 2009 Aug 27;361(9):932-4 - PubMed
  18. Circulation. 2002 Oct 8;106(15):1974-9 - PubMed
  19. Circulation. 2012 Dec 18;126(25):2976-82 - PubMed
  20. J Hypertens. 2012 Nov;30(11):2230-9 - PubMed
  21. Lancet. 2005 Jan 15-21;365(9455):217-23 - PubMed
  22. J Am Soc Nephrol. 2009 May;20(5):933-9 - PubMed
  23. Eur Heart J. 2013 Jul;34(28):2132-40 - PubMed
  24. J Hypertens. 2013 Jul;31(7):1281-357 - PubMed
  25. J Am Med Assoc. 1947 May 3;134(1):1-9 - PubMed
  26. Transplantation. 2001 Sep 27;72(6):1153-5 - PubMed
  27. Am J Physiol. 1980 May;238(5):R353-8 - PubMed
  28. Int J Cardiol. 2013 Oct 3;168(3):2214-20 - PubMed
  29. Hypertension. 2009 Oct;54(4):690-7 - PubMed
  30. J Am Coll Cardiol. 2011 Sep 6;58(11):1176-82 - PubMed
  31. Am J Physiol Regul Integr Comp Physiol. 2010 Feb;298(2):R245-53 - PubMed
  32. Hypertension. 2012 Feb;59(2):467-76 - PubMed
  33. Int J Cardiol. 2013 Jan 20;162(3):189-92 - PubMed
  34. Hypertension. 2003 Dec;42(6):1206-52 - PubMed
  35. Lancet. 2009 Apr 11;373(9671):1275-81 - PubMed
  36. Hypertension. 2012 Aug;60(2):419-24 - PubMed
  37. Clin Res Cardiol. 2011 Dec;100(12):1049-57 - PubMed
  38. J Hypertens. 2012 May;30(5):837-41 - PubMed
  39. Curr Hypertens Rep. 2011 Aug;13(4):303-8 - PubMed
  40. Clin Exp Pharmacol Physiol. 1999 Jan;26(1):32-4 - PubMed
  41. Clin Res Cardiol. 2011 Dec;100(12):1095-101 - PubMed
  42. Am J Physiol Renal Physiol. 2011 Jan;300(1):F31-9 - PubMed
  43. Clin Chim Acta. 2011 Nov 20;412(23-24):2157-61 - PubMed
  44. Lancet. 2010 Dec 4;376(9756):1903-9 - PubMed
  45. Hypertension. 2011 May;57(5):911-7 - PubMed
  46. Cinci J Med. 1947 Oct;28(10):637-56 - PubMed
  47. Am J Hypertens. 2004 Mar;17(3):217-22 - PubMed
  48. Int J Hypertens. 2011 Jan 20;2011:642416 - PubMed
  49. Curr Hypertens Rep. 2002 Apr;4(2):136-42 - PubMed
  50. EuroIntervention. 2013 May;9 Suppl R:R83-8 - PubMed
  51. Physiol Rev. 1991 Jul;71(3):659-82 - PubMed
  52. World J Cardiol. 2013 Apr 26;5(4):94-101 - PubMed
  53. Hypertension. 2009 Dec;54(6):1195-201 - PubMed
  54. J Am Med Assoc. 1953 Aug 15;152(16):1501-4 - PubMed

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