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Hessen E, Reinvang I, Eliassen CF, et al. The Combination of Dysexecutive and Amnestic Deficits Strongly Predicts Conversion to Dementia in Young Mild Cognitive Impairment Patients: A Report from the Gothenburg-Oslo MCI Study. Dement Geriatr Cogn Dis Extra. 2014;4(1):76-85doi: 10.1159/000360282.
Hessen, E., Reinvang, I., Eliassen, C. F., Nordlund, A., Gjerstad, L., Fladby, T., & Wallin, A. (2014). The Combination of Dysexecutive and Amnestic Deficits Strongly Predicts Conversion to Dementia in Young Mild Cognitive Impairment Patients: A Report from the Gothenburg-Oslo MCI Study. Dementia and geriatric cognitive disorders extra, 4(1), 76-85. https://doi.org/10.1159/000360282
Hessen, Erik, et al. "The Combination of Dysexecutive and Amnestic Deficits Strongly Predicts Conversion to Dementia in Young Mild Cognitive Impairment Patients: A Report from the Gothenburg-Oslo MCI Study." Dementia and geriatric cognitive disorders extra vol. 4,1 (2014): 76-85. doi: https://doi.org/10.1159/000360282
Hessen E, Reinvang I, Eliassen CF, Nordlund A, Gjerstad L, Fladby T, Wallin A. The Combination of Dysexecutive and Amnestic Deficits Strongly Predicts Conversion to Dementia in Young Mild Cognitive Impairment Patients: A Report from the Gothenburg-Oslo MCI Study. Dement Geriatr Cogn Dis Extra. 2014 Apr 09;4(1):76-85. doi: 10.1159/000360282. eCollection 2014 Jan. PMID: 24847346; PMCID: PMC4024495.
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Dement Geriatr Cogn Dis Extra. 2014 Apr 09;4(1):76-85. doi: 10.1159/000360282. eCollection 2014 Jan.

The Combination of Dysexecutive and Amnestic Deficits Strongly Predicts Conversion to Dementia in Young Mild Cognitive Impairment Patients: A Report from the Gothenburg-Oslo MCI Study.

Dementia and geriatric cognitive disorders extra

Erik Hessen, Ivar Reinvang, Carl F Eliassen, Arto Nordlund, Leif Gjerstad, Tormod Fladby, Anders Wallin

Affiliations

  1. Department of Neurology, Akershus University Hospital, Oslo, Norway ; Clinical Neuroscience Research Group, Department of Psychology, University of Oslo, Norway.
  2. Clinical Neuroscience Research Group, Department of Psychology, University of Oslo, Norway.
  3. Institute of Neuroscience and Physiology, Sahlgrenska Academy at Gothenburg University, Mölndal, Sweden.
  4. Faculty of Medicine, University of Oslo, Norway ; Department of Neurology, Oslo University Hospital, Oslo, Norway.
  5. Department of Neurology, Akershus University Hospital, Oslo, Norway ; Faculty of Medicine, University of Oslo, Norway.

PMID: 24847346 PMCID: PMC4024495 DOI: 10.1159/000360282

Abstract

BACKGROUND/AIMS: The present study aimed to add to the knowledge of mild cognitive impairment (MCI) by studying the prognosis in a relatively young cohort of patients characterized by neuropsychological criteria.

METHODS: PATIENTS (MEAN AGE: 63 years) with cognitive complaints and MCI (n = 302) were recruited from two university clinics and followed for 2 years.

RESULTS: Pure dysexecutive MCI occurred in 11.7% of the neuropsychologically impaired patients, while 59.3 and 29.0% were characterized as having pure amnestic MCI or multidomain MCI. During the study period, the state of 2 (10.5%) of the patients with single-domain dysexecutive MCI converted to dementia, while 28 (29.2%) of the patients with pure amnestic MCI became demented. Of the patients with both executive and amnestic deficits, 28 (59.6%) became demented.

CONCLUSION: The results suggest that dysexecutive symptoms in combination with amnestic symptoms constitute a strong risk factor for dementia in young MCI patients. A significant number of patients in all subgroups showed normal test results at follow-up, indicating that a neuropsychological diagnosis needs to be supported by imaging or biomarker data.

Keywords: Amnestic mild cognitive impairment; Dysexecutive mild cognitive impairment; Multidomain mild cognitive impairment; Prognosis of mild cognitive impairment

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