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Ghanbari-Niaki A, Zare-Kookandeh N, Zare-Kookandeh A. ABCG5 gene responses to treadmill running with or without administration of Pistachio atlantica in female rats. Iran J Basic Med Sci. 2014;17(3):162-71
Ghanbari-Niaki, A., Zare-Kookandeh, N., & Zare-Kookandeh, A. (2014). ABCG5 gene responses to treadmill running with or without administration of Pistachio atlantica in female rats. Iranian journal of basic medical sciences, 17(3), 162-71.
Ghanbari-Niaki, Abbass, et al. "ABCG5 gene responses to treadmill running with or without administration of Pistachio atlantica in female rats." Iranian journal of basic medical sciences vol. 17,3 (2014): 162-71.
Ghanbari-Niaki A, Zare-Kookandeh N, Zare-Kookandeh A. ABCG5 gene responses to treadmill running with or without administration of Pistachio atlantica in female rats. Iran J Basic Med Sci. 2014 Mar;17(3):162-71. PMID: 24847418; PMCID: PMC4016686.
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Iran J Basic Med Sci. 2014 Mar;17(3):162-71.

ABCG5 gene responses to treadmill running with or without administration of Pistachio atlantica in female rats.

Iranian journal of basic medical sciences

Abbass Ghanbari-Niaki, Navabeh Zare-Kookandeh, Asghar Zare-Kookandeh

Affiliations

  1. Exercise Biochemistry Division, Faculty of Physical Education and Sport Science, University of Mazandaran, Baboulsar, Mazandaran, Iran.
  2. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 24847418 PMCID: PMC4016686

Abstract

OBJECTIVE(S): ABC transporters comprise a large family of transmembrane proteins that use the energy provided by ATP hydrolysis to translocate a variety of substrates across biological membranes. All members of the human ABCG subfamily, except for ABCG2, are cholesterol-transporter. The aim of this study was to determine the liver, the small intestine and kidney ABCG5 relative gene expression in response to treadmill-running training in female rats.

MATERIALS AND METHODS: Twenty Wistar rats (6-8 weeks old and 125-135 g weight) were used. Animals were randomly assigned to saline-control (SC), saline-training (ST), and Baneh-control (BC), and Baneh-training (BT) groups. Training groups did the exercise on a motor-driven treadmill at 25 m/min (0% grade) for 60 min/day for eight weeks (5 days/week). Rats were fed orally, with Baneh extraction and saline for six weeks. The two-way ANOVA was employed for statistical analysis. ABCG5 relative gene expression was detected by Real-time PCR method.

RESULTS: The current findings indicate that the Baneh-treated tissues had significantly lower levels of ABCG5 gene expression in the liver, small intestine, and kidneys (P< 0.001, P< 0.003, P< 0.001, respectively), when compared with saline-treated tissues. However, a higher level of gene expression was observed in exercise groups. A lower level of HDL-c but not triglyceride (TG) and total cholesterol (TC) levels were found in Baneh-treated animals at rest.

CONCLUSION: Exercise training increases ABCG5 relative gene expression in the liver, small intestine and kidney tissues; therefore exercise training may adjust the reduction of ABCG5 relative gene expression in Baneh-training group.

Keywords: ABC transporters; ABCG5; Female rats; Pistachia atlantica; Treadmill exercise

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